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10년간 단일 기관에서 간세포암의 수술적 절제의 경험 - 수술 후 장기 성적을 향상시킬 수 있는 전략
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강창무 | - |
dc.contributor.author | 김경식 | - |
dc.contributor.author | 박영년 | - |
dc.contributor.author | 박준용 | - |
dc.contributor.author | 이우정 | - |
dc.contributor.author | 최진섭 | - |
dc.contributor.author | 한대훈 | - |
dc.date.accessioned | 2018-12-03T01:57:40Z | - |
dc.date.available | 2018-12-03T01:57:40Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1738-6349 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165961 | - |
dc.description.abstract | Purpose: Although surgical resection is the most effective treatment for hepatocellular 4 carcinoma (HCC), high recurrence after resection is a major challenging problem. We attempted to determine the optimal strategies for improving the long-term surgical outcome through the review of our 10 years’ experience with surgically treating HCC. Methods: We retrospectively reviewed 497 patients who received curative resection at the Yonsei University Health System from January 1996 to August 2006. Results: The 5 year disease-free rate and the overall survival rate after curative resection were 45.0% and 63.9%, respectively. Of the 497 patients, 491 (98.8%) were Child-Pugh A and 107 (56.3%) were diagnosed with liver cirrhosis. The postoperative complication and mortality rates were 28.6% and 1.8%, respectively. Of the 243 recurrent patients, 184 (75.7%) were diagnosed with intrahepatic recurrence alone. Of these intrahepatic recurrent patients, 169 (91.9%) received active treatment, including transplantation (n=7), re-resection (n=12), local ablation therapy (n=18) and transarterial chemoembolization (n=132). Multivariate analysis revealed that perioperative transfusion, a satellite nodule, the pathologic TNM stage, the Edmondsons-Steiner grade, the serum alkaline phosphatase (ALP) and aspartate aminotransferase levels and cirrhosis were associated with disease free survival, and perioperative transfusion, a satellite nodule, macroscopic vascular invasion, the Edmondsons-Steiner grade, the ALP and serum albumin levels and the platelet count were related with overall survival after resection. Conclusions: The long-term surgical outcome of HCC can be further improved by proper patient selection, delicately performed surgery and administering postoperative adjuvant therapy for patients with a high risk of recurrence. Early diagnosis and aggressive treatment are needed to treat the recurrence. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | Korean Journal of Hepato-Biliary-Pancreatic Surgery | - |
dc.publisher | Korean Journal of Hepato-Biliary-Pancreatic Surgery | - |
dc.relation.isPartOf | Korean Journal of Hepato-Biliary-Pancreatic Surgery | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 10년간 단일 기관에서 간세포암의 수술적 절제의 경험 - 수술 후 장기 성적을 향상시킬 수 있는 전략 | - |
dc.title.alternative | Single Center Experience (Ten Years) with Surgical Resection for Treating Hepatocellular Carcinoma - Strategies for improving the long-term survival after resection | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | 한대훈 | - |
dc.contributor.googleauthor | 최기홍 | - |
dc.contributor.googleauthor | 김동현 | - |
dc.contributor.googleauthor | 최새별 | - |
dc.contributor.googleauthor | 강창무 | - |
dc.contributor.googleauthor | 김경식 | - |
dc.contributor.googleauthor | 최진섭 | - |
dc.contributor.googleauthor | 박영년 | - |
dc.contributor.googleauthor | 박준용 | - |
dc.contributor.googleauthor | 김도영 | - |
dc.contributor.googleauthor | 한광협 | - |
dc.contributor.googleauthor | 전재윤 | - |
dc.contributor.googleauthor | 이우정 | - |
dc.contributor.localId | A00088 | - |
dc.contributor.localId | A00299 | - |
dc.contributor.localId | A01563 | - |
dc.contributor.localId | A01675 | - |
dc.contributor.localId | A02993 | - |
dc.contributor.localId | A04199 | - |
dc.contributor.localId | A04273 | - |
dc.relation.journalcode | J02035 | - |
dc.identifier.eissn | 2288-9213 | - |
dc.subject.keyword | hepatocellular carcinoma | - |
dc.subject.keyword | curative resection | - |
dc.subject.keyword | long-term outcome | - |
dc.contributor.alternativeName | Kang, Chang Moo | - |
dc.contributor.affiliatedAuthor | 강창무 | - |
dc.contributor.affiliatedAuthor | 김경식 | - |
dc.contributor.affiliatedAuthor | 박영년 | - |
dc.contributor.affiliatedAuthor | 박준용 | - |
dc.contributor.affiliatedAuthor | 이우정 | - |
dc.contributor.affiliatedAuthor | 최진섭 | - |
dc.contributor.affiliatedAuthor | 한대훈 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 245 | - |
dc.citation.endPage | 253 | - |
dc.identifier.bibliographicCitation | Korean Journal of Hepato-Biliary-Pancreatic Surgery, Vol.12(4) : 245-253, 2008 | - |
dc.identifier.rimsid | 57831 | - |
dc.type.rims | ART | - |
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