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Cancer Risk in Patients with Intestinal Behçet's Disease: A Nationwide Population-Based Study

 Minkyung Han  ;  Yoon Suk Jung  ;  Won Ho Kim  ;  Jae Hee Cheon  ;  Sohee Park 
 Gut and Liver, Vol.12(4) : 433-439, 2018 
Journal Title
 Gut and Liver 
Issue Date
Adult ; Behcet Syndrome/complications* ; Female ; Hematologic Neoplasms/epidemiology ; Hematologic Neoplasms/etiology* ; Humans ; Incidence ; Intestinal Diseases/complications* ; Male ; Middle Aged ; Neoplasms/epidemiology ; Neoplasms/etiology ; Republic of Korea/epidemiology ; Risk Factors ; Sex Factors
Intestinal Behçet’s disease ; Neoplasms ; Population-based
Background/Aims: The relationship between intestinal Behçet's disease (BD) and cancer remains unclear. We conducted a nationwide ; population-based study to determine the risk of cancer in patients with intestinal BD. Methods: Using the National Health Insurance claims records ; we collected data on 365 patients who had been diagnosed with intestinal BD between 2011 and 2014. Standardized incidence ratios (SIRs) of overall and site-specific cancers in patients with intestinal BD in comparison with the general population were calculated. Results: Among 167 men with intestinal BD ; four cases of cancer were observed; among 191 women with BD ; eight cases of cancer were observed. The risk of all cancers was significantly higher in women with intestinal BD than in women of the general population (SIR ; 4.27; 95% confidence interval [CI] ; 1.84 to 8.41). However ; in men with intestinal BD ; the risk of all cancers was not significantly higher than that in men of the general population (SIR ; 2.08; 95% CI ; 0.57 to 5.33). The risk of hematologic cancer was significantly higher in both men and women with intestinal BD than in their counterparts in the general population (SIR ; 23.90; 95% CI ; 2.89 to 86.32 in men; SIR ; 34.47; 95% CI ; 4.17 to 124.51 in women). In particular ; patients with intestinal BD showed a higher risk of leukemia and myelodysplastic syndrome than the general population. Conclusions: Patients with intestinal BD demonstrated a higher risk of hematologic cancer ; especially leukemia ; than the general population. Furthermore ; women with intestinal BD showed a higher risk of all cancers.
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1. Journal Papers (연구논문) > 4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원)
Yonsei Authors
한민경(Han, Minkyung) ORCID logo https://orcid.org/0000-0002-5011-5557
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