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Deformable model with surface registration for hippocampal shape deformity analysis in schizophrenia

Authors
 Jong-Min Lee  ;  Sun Hyung Kim  ;  Dong Pyo Jang  ;  Tae Hyon Ha  ;  Jae-Jin Kim  ;  In Young Kim  ;  Jun Soo Kwon  ;  Sun I. Kim 
Citation
 Neuroimage, Vol.22(2) : 831-840, 2004 
Journal Title
 Neuroimage 
ISSN
 1053-8119 
Issue Date
2004
MeSH
Adult ; Female ; Functional Laterality ; Hippocampus/anatomy & histology* ; Hippocampus/pathology* ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging/methods ; Male ; Models, Neurological ; Reference Values ; Schizophrenia/pathology*
Keywords
SchizophreniaHippocampusMRIShape analysisDeformable modelAlignmentSchizophrenia ; Hippocampus ; MRI ; Shape analysis ; Deformable model ; Alignment
Abstract
Changes to the hippocampal structure have been reported as consistent structural abnormalities in schizophrenic patients and have been related to the learning and memory deficits in such patients. Although many magnetic resonance (MR) imaging studies have focused on the hippocampal volume, local structural changes were difficult to discriminate from normal neuroanatomical variations. 3D shape deformation analysis of the brain structure may reflect localized schizophrenic abnormalities. A deformable model, evolved from the ellipsoid to hippocampal surface, with 2562 vertexes, was developed to analyze the left and right hippocampus shapes in 22 schizophrenic patients and 22 healthy age and gender matched controls. One of the most critical issues in the shape analysis is the determination of homologous points between two objects. To determine more accurate corresponding points, an alignment procedure, consisting of coarse and fine steps, following a deformation process, was applied. The performance of the alignment process was tested using artificial data, to get the alignment error to within 3 degrees for each angle. A volume analysis indicated the hippocampal volume to be bilaterally reduced in schizophrenic patients compared to the normal controls, with a shape analysis showing a deformity pattern of the hippocampal surface. Bilateral inward deformities in the anterior and posterior hippocampus and a unilateral outward deformity in the right anterior hippocampus were observed, respectively
DOI
10.1016/j.neuroimage.2004.02.004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165909
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