Pluronic® F127 하이드로젤과 규산칼슘 하이브리드 골수복재의 탐색 연구

Abstract

Calcium silicate cement, which is known as Mineral trioxide aggregate, usually mixed with distilled water. It showed limitation in manipulation and setting mechanism. To overcome its character, we modified the liquid to thermoreversible hydrogel, F-127. So, we developed hybrid bone graft materials with calcium silicate and hydrogel. And we measured their phase transition temperature using differential scanning calorimetry (DSC) and evaluated physical properties, film thickness, surface texture, ability to manipulation and flow change according to temperature change. Various concentration of hydrogel (5, 10, 20, 30 and 40 wt%) was mixed with calcium silicate cement in 1:0.3 ratios and was coded H5, H10, H20, H30 and H40. The original calcium silicate cement with distilled water was used as control (MDW). To evaluate their physical characteristics, film thickness was measured according to ISO 9917-1 and surface texture and flow properties were compared. As the concentration of F-127 increased, the transition temperature was decreased. In H20 and H30 showed significantly lower film thickness with creamy texture and gelation at 37℃. In conclusion, the hybrid with hydrogel and calcium silicate cement, especially H20 and H30, was candidate combinations might be a candidate as useful bone graft materials.