Cited 9 times in
Efficacy and safety of dual antiplatelet therapy after coronary stenting in patients with chronic kidney disease
DC Field | Value | Language |
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dc.contributor.author | 홍명기 | - |
dc.date.accessioned | 2018-11-26T05:57:23Z | - |
dc.date.available | 2018-11-26T05:57:23Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0002-8703 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165837 | - |
dc.description.abstract | BACKGROUND: We compared efficacy and safety of short- (3 or 6 months) versus long-term (≥12 months) dual antiplatelet therapy (DAPT) after drug-eluting stent (DES) implantation, according to the presence of chronic kidney disease (CKD). METHODS: Patient-level pooled analysis was performed with 7242 patients (87.2% with 2nd generation DES) from 5 randomized controlled trials. RESULTS: In both CKD (1273 patients) and non-CKD (5969 patients) population, the rates of patient-oriented composite outcomes at 1-year (POCO, all-cause death, any myocardial infarction [MI], stroke and TIMI major bleeding) were not different between the short- and long-term DAPT (hazard ratio [HR] 1.19, 95% confidence interval [CI] 0.76-1.86, P=.449 in CKD population; HR 1.14, 95% CI 0.83-1.56, P=.434 in non-CKD population). The rates of coronary thrombotic events (any MI and definite/probable stent thrombosis) also did not differ between short- and long-term DAPT in either CKD or non-CKD population. As for bleeding events, long-term DAPT increased the TIMI major bleeding (HR 2.91, 95% CI 1.31-6.48, P=.009) in non-CKD population. The similar trend was observed with long-term DAPT in CKD population. But it did not reach statistical significance (HR 3.15, 95% CI 0.64-15.63, P=.160). CONCLUSIONS: The rates of POCO and coronary thrombotic events were significantly higher in patients with CKD compared with those without CKD, which were not affected by short- or long-term DAPT. Higher bleeding incidence by long-term DAPT was only observed in non-CKD patients but not in CKD patients. Further large scale studies are warranted to confirm our findings. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Mosby | - |
dc.relation.isPartOf | AMERICAN HEART JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Efficacy and safety of dual antiplatelet therapy after coronary stenting in patients with chronic kidney disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Doyeon Hwang | - |
dc.contributor.googleauthor | Kyung Woo Park | - |
dc.contributor.googleauthor | Joo Myung Lee | - |
dc.contributor.googleauthor | Tae-Min Rhee | - |
dc.contributor.googleauthor | Myeong-Ki Hong | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Marco Valgimigli | - |
dc.contributor.googleauthor | Antonio Colombo | - |
dc.contributor.googleauthor | Martine Gilard | - |
dc.contributor.googleauthor | Tullio Palmerini | - |
dc.contributor.googleauthor | Gregg W. Stone | - |
dc.contributor.googleauthor | Hyo-Soo Kim | - |
dc.identifier.doi | 10.1016/j.ahj.2017.11.013 | - |
dc.contributor.localId | A04391 | - |
dc.relation.journalcode | J00069 | - |
dc.identifier.eissn | 1097-6744 | - |
dc.identifier.pmid | 29447770 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0002870317303800 | - |
dc.contributor.alternativeName | Hong, Myeong Ki | - |
dc.contributor.affiliatedAuthor | 홍명기 | - |
dc.citation.volume | 197 | - |
dc.citation.startPage | 103 | - |
dc.citation.endPage | 112 | - |
dc.identifier.bibliographicCitation | AMERICAN HEART JOURNAL, Vol.197 : 103-112, 2018 | - |
dc.identifier.rimsid | 60827 | - |
dc.type.rims | ART | - |
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