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Clinical signs and symptoms associated with increased risk for thrombosis in patients with paroxysmal nocturnal hemoglobinuria from a Korean Registry.

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dc.contributor.author김진석-
dc.date.accessioned2018-11-23T11:33:17Z-
dc.date.available2018-11-23T11:33:17Z-
dc.date.issued2013-
dc.identifier.issn0925-5710-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/165804-
dc.description.abstractParoxysmal nocturnal hemoglobinuria (PNH) is characterized by chronic, complement-mediated hemolysis, frequently leading to debilitating clinical symptoms and life-threatening complications such as thromboembolism (TE). A retrospective analysis was performed on 301 patients from the South Korean National PNH Registry to describe disease burden and identify TE-associated risk factors. TE was identified in 18 % of patients and was associated with increased risk for mortality [odds ratio (OR), 6.85; P < 0.001]. A multivariate analysis showed that PNH patients with elevated hemolysis [lactate dehydrogenase (LDH) levels ≥1.5 times the upper limit of normal (ULN)] at diagnosis were at significantly higher risk for TE than patients with LDH <1.5 × ULN (OR 7.0; P = 0.013). The combination of LDH ≥1.5 × ULN with the clinical symptoms of abdominal pain, chest pain, dyspnea, or hemoglobinuria was associated with a greater increased risk for TE than elevated hemolysis or clinical symptoms alone. Continuous monitoring of these risk factors is critical for identifying PNH patients at risk for morbidities and mortality and allowing early intervention.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer Japan-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF HEMATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHChild-
dc.subject.MESHFemale-
dc.subject.MESHHemoglobinuria, Paroxysmal/complications*-
dc.subject.MESHHemoglobinuria, Paroxysmal/diagnosis-
dc.subject.MESHHumans-
dc.subject.MESHLactate Dehydrogenases/metabolism-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHROC Curve-
dc.subject.MESHRegistries-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHThromboembolism/diagnosis-
dc.subject.MESHThromboembolism/etiology-
dc.subject.MESHThrombosis/diagnosis*-
dc.subject.MESHThrombosis/etiology*-
dc.subject.MESHYoung Adult-
dc.titleClinical signs and symptoms associated with increased risk for thrombosis in patients with paroxysmal nocturnal hemoglobinuria from a Korean Registry.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJong Wook Lee-
dc.contributor.googleauthorJun Ho Jang-
dc.contributor.googleauthorJin Seok Kim-
dc.contributor.googleauthorSung-Soo Yoon-
dc.contributor.googleauthorJe-Hwan Lee-
dc.contributor.googleauthorYeo-Kyeoung Kim-
dc.contributor.googleauthorDeog-Yeon Jo-
dc.contributor.googleauthorJooseop Chung-
dc.contributor.googleauthorSang Kyun Sohn-
dc.identifier.doi10.1007/s12185-013-1346-4-
dc.contributor.localIdA01017-
dc.relation.journalcodeJ01120-
dc.identifier.eissn1865-3774-
dc.identifier.pmid23636668-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs12185-013-1346-4-
dc.subject.keywordRisk Factor-
dc.subject.keywordHemolysis-
dc.subject.keywordThrombosis-
dc.subject.keywordMortality-
dc.subject.keywordParoxysmal nocturnal hemoglobinuria-
dc.contributor.alternativeNameKim, Jin Seok-
dc.contributor.affiliatedAuthor김진석-
dc.citation.volume97-
dc.citation.number6-
dc.citation.startPage749-
dc.citation.endPage757-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF HEMATOLOGY, Vol.97(6) : 749-757, 2013-
dc.identifier.rimsid60545-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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