Cited 60 times in
Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection
DC Field | Value | Language |
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dc.contributor.author | 박혜정 | - |
dc.date.accessioned | 2018-11-23T11:32:34Z | - |
dc.date.available | 2018-11-23T11:32:34Z | - |
dc.date.issued | 2017-01 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165796 | - |
dc.description.abstract | The N-terminal truncated form of a protein synthesis enzyme, tryptophanyl-tRNA synthetase (mini-WRS), is secreted as an angiostatic ligand. However, the secretion and function of the full-length WRS (FL-WRS) remain unknown. Here, we report that the FL-WRS, but not mini-WRS, is rapidly secreted upon pathogen infection to prime innate immunity. Blood levels of FL-WRS were increased in sepsis patients, but not in those with sterile inflammation. FL-WRS was secreted from monocytes and directly bound to macrophages via a toll-like receptor 4 (TLR4)-myeloid differentiation factor 2 (MD2) complex to induce phagocytosis and chemokine production. Administration of FL-WRS into Salmonella typhimurium-infected mice reduced the levels of bacteria and improved mouse survival, whereas its titration with the specific antibody aggravated the infection. The N-terminal 154-amino-acid eukaryote-specific peptide of WRS was sufficient to recapitulate FL-WRS activity and its interaction mode with TLR4-MD2 is now suggested. Based on these results, secretion of FL-WRS appears to work as a primary defence system against infection, acting before full activation of innate immunity. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.relation.isPartOf | Nature Microbiology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bacterial Infections/immunology* | - |
dc.subject.MESH | Bacterial Infections/pathology | - |
dc.subject.MESH | Bacterial Load | - |
dc.subject.MESH | Chemokines/secretion | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunity, Innate* | - |
dc.subject.MESH | Immunologic Factors/administration & dosage | - |
dc.subject.MESH | Immunologic Factors/blood | - |
dc.subject.MESH | Immunologic Factors/secretion* | - |
dc.subject.MESH | Macrophages/immunology | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Monocytes/immunology | - |
dc.subject.MESH | Phagocytosis | - |
dc.subject.MESH | Salmonella Infections, Animal | - |
dc.subject.MESH | Salmonella typhimurium/isolation & purification | - |
dc.subject.MESH | Sepsis/immunology | - |
dc.subject.MESH | Sepsis/pathology | - |
dc.subject.MESH | Survival Analysis | - |
dc.subject.MESH | Tryptophan-tRNA Ligase/administration & dosage | - |
dc.subject.MESH | Tryptophan-tRNA Ligase/blood | - |
dc.subject.MESH | Tryptophan-tRNA Ligase/secretion* | - |
dc.title | Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Young Ha Ahn | - |
dc.contributor.googleauthor | Sunyoung Park | - |
dc.contributor.googleauthor | Jeong June Choi | - |
dc.contributor.googleauthor | Bo-Kyung Park | - |
dc.contributor.googleauthor | Kyung Hee Rhee | - |
dc.contributor.googleauthor | Eunjoo Kang | - |
dc.contributor.googleauthor | Soyeon Ahn | - |
dc.contributor.googleauthor | Chul-Ho Lee | - |
dc.contributor.googleauthor | Jong Soo Lee | - |
dc.contributor.googleauthor | Kyung-Soo Inn | - |
dc.contributor.googleauthor | Mi-La Cho | - |
dc.contributor.googleauthor | Sung-Hwan Park | - |
dc.contributor.googleauthor | Kyunghee Park | - |
dc.contributor.googleauthor | Hye Jung Park | - |
dc.contributor.googleauthor | Jae-Hyun Lee | - |
dc.contributor.googleauthor | Jung-Won Park | - |
dc.contributor.googleauthor | Nam Hoon Kwon | - |
dc.contributor.googleauthor | Hyunbo Shim | - |
dc.contributor.googleauthor | Byung Woo Han | - |
dc.contributor.googleauthor | Pilhan Kim | - |
dc.contributor.googleauthor | Joo-Youn Lee | - |
dc.contributor.googleauthor | Youngho Jeon | - |
dc.contributor.googleauthor | Jin Won Huh | - |
dc.contributor.googleauthor | Mirim Jin | - |
dc.contributor.googleauthor | Sunghoon Kim | - |
dc.identifier.doi | 10.1038/nmicrobiol.2016.191 | - |
dc.contributor.localId | A01769 | - |
dc.contributor.localId | A01427 | - |
dc.contributor.localId | A03086 | - |
dc.contributor.localId | A01681 | - |
dc.relation.journalcode | J03537 | - |
dc.identifier.pmid | 27748732 | - |
dc.identifier.url | https://www.nature.com/articles/nmicrobiol2016191 | - |
dc.contributor.alternativeName | Park, Hye Jung | - |
dc.contributor.affiliatedAuthor | 박혜정 | - |
dc.contributor.affiliatedAuthor | 박경희 | - |
dc.contributor.affiliatedAuthor | 이재현 | - |
dc.contributor.affiliatedAuthor | 박중원 | - |
dc.citation.volume | 2 | - |
dc.citation.startPage | 16191 | - |
dc.identifier.bibliographicCitation | Nature Microbiology, Vol.2 : 16191, 2017-01 | - |
dc.identifier.rimsid | 60537 | - |
dc.type.rims | ART | - |
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