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Chemopreventive and Anticancer Activities of Allium victorialis var. platyphyllum Extracts
DC Field | Value | Language |
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dc.contributor.author | 김현정 | - |
dc.date.accessioned | 2018-11-23T11:32:26Z | - |
dc.date.available | 2018-11-23T11:32:26Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 2288-3649 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165794 | - |
dc.description.abstract | BACKGROUND: Allium victorialis var. platyphyllum is an edible perennial herb and has been used as a vegetable or as a Korean traditional medicine. Allium species have received much attention owing to their diverse pharmacological properties, including antioxidative, anti-inflammatory, and anticancer activities. However, A. victorialis var. platyphyllum needs more study. METHODS: The chemopreventive potential of A. victorialis var. platyphyllum methanol extracts was examined by measuring 12-O-tetra-decanoylphorbol 13-acetate (TPA)-induced superoxide anion production in the differentiated HL-60 cells, TPA-induced mouse ear edema, and Ames/Salmonella mutagenicity. The apoptosis-inducing capabilities of the extracts were evaluated by the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide assay, 4',6-diamidino-2-phenylindole staining, and the DNA fragmentation assay in human colon cancer HT-29 cells. Antimetastatic activities of the extracts were also investigated in an experimental mouse lung metastasis model. RESULTS: The methanol extracts of A. victorialis var. platyphyllum rhizome (AVP-R) and A. victorialis var. platyphyllum stem (AVP-S) dose-dependently inhibited the TPA-induced generation of superoxide anion in HL-60 cells and TPA-induced ear edema in mice, as well as 7,12-dimethylbenz[a]anthracene (DMBA) and tert-butyl hydroperoxide (t-BOOH) -induced bacterial mutagenesis. AVP-R and AVP-S reduced cell viability in a dose-related manner and induced apoptotic morphological changes and internucleosomal DNA fragmentation in HT-29 cells. In the experimental mouse lung metastasis model, the formation of tumor nodules in lung tissue was significantly inhibited by the treatment of the extracts. CONCLUSIONS: AVP-R and AVP-S possess antioxidative, anti-inflammatory, antimutagenic, proapoptotic, and antimetastatic activities. Therefore, these extracts can serve as a beneficial supplement for the prevention and treatment of cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Korean Society of Cancer Prevention | - |
dc.relation.isPartOf | JOURNAL OF CANCER PREVENTION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Chemopreventive and Anticancer Activities of Allium victorialis var. platyphyllum Extracts | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Hyun-Jeong Kim | - |
dc.contributor.googleauthor | Min Jeong Park | - |
dc.contributor.googleauthor | Hee-Juhn Park | - |
dc.contributor.googleauthor | Won-Yoon Chung | - |
dc.contributor.googleauthor | Ki-Rim Kim | - |
dc.contributor.googleauthor | Kwang-Kyun Park | - |
dc.identifier.doi | 10.15430/JCP.2014.19.3.179 | - |
dc.contributor.localId | A01132 | - |
dc.relation.journalcode | J01282 | - |
dc.identifier.eissn | 2288-3657 | - |
dc.identifier.pmid | 25337587 | - |
dc.subject.keyword | Allium victorialis var. platyphyllum | - |
dc.subject.keyword | Anti-inflammation | - |
dc.subject.keyword | Anti-metastatic activity | - |
dc.subject.keyword | Anti-mutagenicity | - |
dc.subject.keyword | Induction of apoptosis | - |
dc.contributor.alternativeName | Kim, Hyun Jeong | - |
dc.contributor.affiliatedAuthor | 김현정 | - |
dc.citation.volume | 19 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 179 | - |
dc.citation.endPage | 186 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CANCER PREVENTION, Vol.19(3) : 179-186, 2014 | - |
dc.identifier.rimsid | 60535 | - |
dc.type.rims | ART | - |
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