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Chemopreventive and Anticancer Activities of Allium victorialis var. platyphyllum Extracts

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dc.contributor.author김현정-
dc.date.accessioned2018-11-23T11:32:26Z-
dc.date.available2018-11-23T11:32:26Z-
dc.date.issued2014-
dc.identifier.issn2288-3649-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/165794-
dc.description.abstractBACKGROUND: Allium victorialis var. platyphyllum is an edible perennial herb and has been used as a vegetable or as a Korean traditional medicine. Allium species have received much attention owing to their diverse pharmacological properties, including antioxidative, anti-inflammatory, and anticancer activities. However, A. victorialis var. platyphyllum needs more study. METHODS: The chemopreventive potential of A. victorialis var. platyphyllum methanol extracts was examined by measuring 12-O-tetra-decanoylphorbol 13-acetate (TPA)-induced superoxide anion production in the differentiated HL-60 cells, TPA-induced mouse ear edema, and Ames/Salmonella mutagenicity. The apoptosis-inducing capabilities of the extracts were evaluated by the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide assay, 4',6-diamidino-2-phenylindole staining, and the DNA fragmentation assay in human colon cancer HT-29 cells. Antimetastatic activities of the extracts were also investigated in an experimental mouse lung metastasis model. RESULTS: The methanol extracts of A. victorialis var. platyphyllum rhizome (AVP-R) and A. victorialis var. platyphyllum stem (AVP-S) dose-dependently inhibited the TPA-induced generation of superoxide anion in HL-60 cells and TPA-induced ear edema in mice, as well as 7,12-dimethylbenz[a]anthracene (DMBA) and tert-butyl hydroperoxide (t-BOOH) -induced bacterial mutagenesis. AVP-R and AVP-S reduced cell viability in a dose-related manner and induced apoptotic morphological changes and internucleosomal DNA fragmentation in HT-29 cells. In the experimental mouse lung metastasis model, the formation of tumor nodules in lung tissue was significantly inhibited by the treatment of the extracts. CONCLUSIONS: AVP-R and AVP-S possess antioxidative, anti-inflammatory, antimutagenic, proapoptotic, and antimetastatic activities. Therefore, these extracts can serve as a beneficial supplement for the prevention and treatment of cancer.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherKorean Society of Cancer Prevention-
dc.relation.isPartOfJOURNAL OF CANCER PREVENTION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleChemopreventive and Anticancer Activities of Allium victorialis var. platyphyllum Extracts-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학교실)-
dc.contributor.googleauthorHyun-Jeong Kim-
dc.contributor.googleauthorMin Jeong Park-
dc.contributor.googleauthorHee-Juhn Park-
dc.contributor.googleauthorWon-Yoon Chung-
dc.contributor.googleauthorKi-Rim Kim-
dc.contributor.googleauthorKwang-Kyun Park-
dc.identifier.doi10.15430/JCP.2014.19.3.179-
dc.contributor.localIdA01132-
dc.relation.journalcodeJ01282-
dc.identifier.eissn2288-3657-
dc.identifier.pmid25337587-
dc.subject.keywordAllium victorialis var. platyphyllum-
dc.subject.keywordAnti-inflammation-
dc.subject.keywordAnti-metastatic activity-
dc.subject.keywordAnti-mutagenicity-
dc.subject.keywordInduction of apoptosis-
dc.contributor.alternativeNameKim, Hyun Jeong-
dc.contributor.affiliatedAuthor김현정-
dc.citation.volume19-
dc.citation.number3-
dc.citation.startPage179-
dc.citation.endPage186-
dc.identifier.bibliographicCitationJOURNAL OF CANCER PREVENTION, Vol.19(3) : 179-186, 2014-
dc.identifier.rimsid60535-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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