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Clinical Significance of Four Molecular Subtypes of Gastric Cancer Identified by The Cancer Genome Atlas Project

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dc.contributor.author노성훈-
dc.contributor.author조재용-
dc.contributor.author정재호-
dc.date.accessioned2018-11-23T10:53:19Z-
dc.date.available2018-11-23T10:53:19Z-
dc.date.issued2017-
dc.identifier.issn1078-0432-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/165783-
dc.description.abstractPurpose: The Cancer Genome Atlas (TCGA) project recently uncovered four molecular subtypes of gastric cancer: Epstein-Barr virus (EBV), microsatellite instability (MSI), genomically stable (GS), and chromosomal instability (CIN). However, their clinical significances are currently unknown. We aimed to investigate the relationship between subtypes and prognosis of patients with gastric cancer.Experimental Design: Gene expression data from a TCGA cohort (n = 262) were used to develop a subtype prediction model, and the association of each subtype with survival and benefit from adjuvant chemotherapy was tested in 2 other cohorts (n = 267 and 432). An integrated risk assessment model (TCGA risk score) was also developed.Results: EBV subtype was associated with the best prognosis, and GS subtype was associated with the worst prognosis. Patients with MSI and CIN subtypes had poorer overall survival than those with EBV subtype but better overall survival than those with GS subtype (P = 0.004 and 0.03 in two cohorts, respectively). In multivariate Cox regression analyses, TCGA risk score was an independent prognostic factor [HR, 1.5; 95% confidence interval (CI), 1.2-1.9; P = 0.001]. Patients with the CIN subtype experienced the greatest benefit from adjuvant chemotherapy (HR, 0.39; 95% CI, 0.16-0.94; P = 0.03) and those with the GS subtype had the least benefit from adjuvant chemotherapy (HR, 0.83; 95% CI, 0.36-1.89; P = 0.65).Conclusions: Our prediction model successfully stratified patients by survival and adjuvant chemotherapy outcomes. Further development of the prediction model is warranted.-
dc.languageEnglish-
dc.publisherAmerican Association for Cancer Research-
dc.relation.isPartOfCLINICAL CANCER RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleClinical Significance of Four Molecular Subtypes of Gastric Cancer Identified by The Cancer Genome Atlas Project-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorBo Hwa Sohn-
dc.contributor.googleauthorJun-Eul Hwang-
dc.contributor.googleauthorHee-Jin Jang-
dc.contributor.googleauthorHyun-Sung Lee-
dc.contributor.googleauthorSang Cheul Oh-
dc.contributor.googleauthorJae-Jun Shim-
dc.contributor.googleauthorKeun-Wook Lee-
dc.contributor.googleauthorEui Hyun Kim-
dc.contributor.googleauthorSun Young Yim-
dc.contributor.googleauthorSang Ho Lee-
dc.contributor.googleauthorJae-Ho Cheong-
dc.contributor.googleauthorWoojin Jeong-
dc.contributor.googleauthorJae Yong Cho-
dc.contributor.googleauthorJoohee Kim-
dc.contributor.googleauthorJungsoo Chae-
dc.contributor.googleauthorJeeyun Lee-
dc.contributor.googleauthorWon Ki Kang-
dc.contributor.googleauthorSung Kim-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorJaffer A. Ajani-
dc.contributor.googleauthorJu-Seog Lee-
dc.identifier.doi10.1158/1078-0432.CCR-16-2211-
dc.contributor.localIdA01281-
dc.contributor.localIdA03899-
dc.relation.journalcodeJ00564-
dc.identifier.pmid28747339-
dc.identifier.urlhttps://aacrjournals.org/clincancerres/article/23/15/4441/257504/-
dc.contributor.alternativeNameNoh, Sung Hoon ::Noh, Sung Hoon ::Noh, Sung Hoon ::Noh, Sung Hoon-
dc.contributor.affiliatedAuthor노성훈-
dc.contributor.affiliatedAuthor조재용-
dc.citation.volume23-
dc.citation.number15-
dc.citation.startPage4441-
dc.citation.endPage4449-
dc.identifier.bibliographicCitationCLINICAL CANCER RESEARCH, Vol.23(15) : 4441-4449, 2017-
dc.identifier.rimsid60361-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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