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Treatment of latent tuberculous infection among health care workers at a tertiary hospital in Korea

 Lee, E. H.  ;  Kim, S. J.  ;  Ha, E. J.  ;  Park, E. S.  ;  Choi, J. Y.  ;  Leem, A. Y.  ;  Kim, S. Y.  ;  Park, M. S.  ;  Kim, Y. S.  ;  Kang, Y. A. 
 International Journal of Tuberculosis and Lung Disease, Vol.22(11) : 1336-1343, 2018 
Journal Title
 International Journal of Tuberculosis and Lung Disease 
Issue Date
OBJECTIVE: To evaluate the acceptance of, adherence to, and outcomes of latent tuberculous infection (LTBI) treatment among health care workers (HCWs). DESIGN: This was a retrospective study in a tertiary hospital in Korea. From May to August 2017, 2190 HCWs simultaneously underwent a tuberculin skin test (TST) and interferon-gamma release assay (IGRA). LTBI was diagnosed if the TST induration was 10 mm or IGRA results were positive. RESULTS: Of 2190 HCWs tested, 1006 (45.9%) were diagnosed with LTBI. Of these, 655 (65.1%) HCWs visited out-patient clinics, 234 (35.7%) of whom were advised treatment by physicians. Among these, 120 (51.3%) accepted the physicians' recommendations. In general, HCWs who were older, male and smoked were less likely to visit out-patient clinics. Sixty (50%) HCWs received 3 months of isoniazid plus rifampicin (3HR) and 57 (47.5%) HCWs received 4 months of rifampicin (4R). The proportion of HCWs with 2 side effects (3HR 20% vs. 4R 7.0%, P = 0.041) and drug stoppage rate (3HR 20% vs. 4R 5.3%, P = 0.017) were higher in the 3HR group than in the 4R group. Of the 120 HCWs, 78 (65%) completed LTBI treatment. CONCLUSION: Overall, the acceptance and completion rate for LTBI treatment was not adequate. For effective LTBI management in HCWs, further programmatic strategies are needed.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
강영애(Kang, Young Ae) ORCID logo https://orcid.org/0000-0002-7783-5271
김송이(Kim, Song Yee) ORCID logo https://orcid.org/0000-0001-8627-486X
김영삼(Kim, Young Sam) ORCID logo https://orcid.org/0000-0001-9656-8482
박무석(Park, Moo Suk) ORCID logo https://orcid.org/0000-0003-0820-7615
이은혜(Lee, Eun Hye) ORCID logo https://orcid.org/0000-0003-2570-3442
임아영(Leem, Ah Young) ORCID logo https://orcid.org/0000-0001-5165-3704
최준용(Choi, Jun Yong) ORCID logo https://orcid.org/0000-0002-2775-3315
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