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Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer

DC FieldValueLanguage
dc.contributor.author임재윤-
dc.contributor.author정재호-
dc.contributor.author조재용-
dc.contributor.author노성훈-
dc.date.accessioned2018-11-20T11:47:14Z-
dc.date.available2018-11-20T11:47:14Z-
dc.date.issued2016-
dc.identifier.issn1078-0432-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/165670-
dc.description.abstractPURPOSE: This study was aimed at developing and validating a quantitative multigene assay for predicting tumor recurrence after gastric cancer surgery. EXPERIMENTAL DESIGN: Gene expression data were generated from tumor tissues of patients who underwent surgery for gastric cancer (n = 267, training cohort). Genes whose expression was significantly associated with activation of YAP1 (a frequently activated oncogene in gastrointestinal cancer), 5-year recurrence-free survival, and 5-year overall survival were first identified as candidates for prognostic genes (156 genes, P < 0.001). We developed the recurrence risk score (RRS) by using quantitative RT-PCR to identify genes whose expression levels were significantly associated with YAP1 activation and patient survival in the training cohort. RESULTS: We based the RRS assay on 6 genes, IGFBP4, SFRP4, SPOCK1, SULF1, THBS, and GADD45B, whose expression levels were significantly associated with YAP1 activation and prognosis in the training cohort. The RRS assay was further validated in an independent cohort of 317 patients. In multivariate analysis, the RRS was an independent predictor of recurrence [HR, 1.6; 95% confidence interval (CI), 1.02-2.4; P = 0.03]. In patients with stage II disease, the RRS had an HR of 2.9 (95% CI, 1.1-7.9; P = 0.03) and was the only significant independent predictor of recurrence. CONCLUSIONS: The RRS assay was a valid predictor of recurrence in the two cohorts of patients with gastric cancer. Independent prospective studies to assess the clinical utility of this assay are warranted. Clin Cancer Res; 22(24); 6228-35. ©2016 AACR.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherAmerican Association for Cancer Research-
dc.relation.isPartOfClinical Cancer Research-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleDevelopment and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer-
dc.typeArticle-
dc.contributor.college1. College of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorKeun-Wook Lee-
dc.contributor.googleauthorSung Sook Lee-
dc.contributor.googleauthorJun-Eul Hwang-
dc.contributor.googleauthorHee-Jin Jang-
dc.contributor.googleauthorHyun-Sung Lee-
dc.contributor.googleauthorSang Cheul Oh-
dc.contributor.googleauthorSang Ho Lee-
dc.contributor.googleauthorBo Hwa Sohn-
dc.contributor.googleauthorSang Bae Kim-
dc.contributor.googleauthorJae Jun Shim-
dc.contributor.googleauthorWoojin Jeong-
dc.contributor.googleauthorMinse Cha-
dc.contributor.googleauthorJae-Ho Cheong-
dc.contributor.googleauthorJae Yong Cho-
dc.contributor.googleauthorJae Yun Lim-
dc.contributor.googleauthorEun Sung Park-
dc.contributor.googleauthorSang-Cheol Kim-
dc.contributor.googleauthorYoon-Koo Kang-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorJaffer A. Ajani-
dc.contributor.googleauthorJu-Seog Lee-
dc.identifier.doi10.1158/1078-0432.CCR-15-2468-
dc.contributor.localIdA01281-
dc.contributor.localIdA03398-
dc.contributor.localIdA03717-
dc.contributor.localIdA03899-
dc.contributor.localIdA04391-
dc.relation.journalcodeJ00564-
dc.identifier.pmid27654712-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNameLim, Jae Yun-
dc.contributor.alternativeNameCheong, Jae Ho-
dc.contributor.alternativeNameCho, Jae Yong-
dc.contributor.affiliatedAuthor노성훈-
dc.contributor.affiliatedAuthor임재윤-
dc.contributor.affiliatedAuthor정재호-
dc.contributor.affiliatedAuthor조재용-
dc.citation.volume22-
dc.citation.number24-
dc.citation.startPage6228-
dc.citation.endPage6235-
dc.identifier.bibliographicCitationClinical Cancer Research, Vol.22(24) : 6228-6235, 2016-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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