Cited 5 times in
The Effects of Losartan in Preserving the Structural Integrity of Decellularized Small Diameter Vascular Allograft Conduit Implants In Vivo.
DC Field | Value | Language |
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dc.contributor.author | 이승현 | - |
dc.date.accessioned | 2018-11-19T16:42:25Z | - |
dc.date.available | 2018-11-19T16:42:25Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1434-7229 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165617 | - |
dc.description.abstract | Decellularization is a proposed method of preparing nonautologous biological arterial vascular scaffolding; however, the fate of the supporting medial elastic fiber, which is important in preserving the vascular structural integrity, is uncertain. The influence of losartan on preserving the medial elastic fiber integrity in decellularized small diameter vascular conduits (SDVC) was investigated. Decellularized infrarenal abdominal aortic allografts were implanted in Sprague-Dawley rats treated either with (study rats, n = 6) or without oral losartan (control rats, n = 6) and graded 8 weeks later according to a remodeling scoring system (1-mild, 2-moderate, 3-severe) which we devised based on the intimal hyperplasia degree, morphologic changes, and elastic fiber fragmentation of the conduits. DAPI immunohistochemistry analysis was performed in 47 (25 decellularization only and 22 losartan treatment) cross-sectional slide specimens. The losartan versus decellularization only SDVC showed a significantly lower medial elastic fragmentation score (1.32 vs. 2.24, P < 0.001), superior medial layer preservation, and relatively more normal appearing intimal cellular morphology. The results suggested rats receiving decellularized SDVCs treated with losartan may yield superior medial layer elastic fiber preservation. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Springer Verlag | - |
dc.relation.isPartOf | JOURNAL OF ARTIFICIAL ORGANS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Allografts | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antihypertensive Agents/pharmacology* | - |
dc.subject.MESH | Aorta, Abdominal/drug effects* | - |
dc.subject.MESH | Aorta, Abdominal/transplantation* | - |
dc.subject.MESH | Aorta, Abdominal/ultrastructure | - |
dc.subject.MESH | Biomechanical Phenomena/drug effects | - |
dc.subject.MESH | Bioprosthesis* | - |
dc.subject.MESH | Blood Vessel Prosthesis* | - |
dc.subject.MESH | Elasticity/drug effects | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Losartan/pharmacology* | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Tissue Scaffolds/chemistry | - |
dc.subject.MESH | Transplantation, Homologous | - |
dc.title | The Effects of Losartan in Preserving the Structural Integrity of Decellularized Small Diameter Vascular Allograft Conduit Implants In Vivo. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) | - |
dc.contributor.googleauthor | Seung Hyun Lee | - |
dc.contributor.googleauthor | Byoung Wook Lee | - |
dc.contributor.googleauthor | Seong Who Kim | - |
dc.contributor.googleauthor | Suk Jung Choo | - |
dc.identifier.doi | 10.1111/aor.12686 | - |
dc.contributor.localId | A02935 | - |
dc.relation.journalcode | J03528 | - |
dc.identifier.eissn | 1619-0904 | - |
dc.identifier.pmid | 27087603 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1111/aor.12686 | - |
dc.subject.keyword | Losartan | - |
dc.subject.keyword | Medial elastic fiber integrity | - |
dc.subject.keyword | Small diameter vascular conduits | - |
dc.contributor.alternativeName | Lee, Seung Hyun | - |
dc.contributor.affiliatedAuthor | 이승현 | - |
dc.citation.volume | 41 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 98 | - |
dc.citation.endPage | 106 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ARTIFICIAL ORGANS, Vol.41(1) : 98-106, 2017 | - |
dc.identifier.rimsid | 59246 | - |
dc.type.rims | ART | - |
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