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The Effects of Losartan in Preserving the Structural Integrity of Decellularized Small Diameter Vascular Allograft Conduit Implants In Vivo.

Authors
 Seung Hyun Lee  ;  Byoung Wook Lee  ;  Seong Who Kim  ;  Suk Jung Choo 
Citation
 Journal of Artificial Organs, Vol.41(1) : 98-106, 2017 
Journal Title
 Journal of Artificial Organs 
ISSN
 1619-0904 
Issue Date
2017
MeSH
Allografts ; Animals ; Antihypertensive Agents/pharmacology* ; Aorta, Abdominal/drug effects* ; Aorta, Abdominal/transplantation* ; Aorta, Abdominal/ultrastructure ; Biomechanical Phenomena/drug effects ; Bioprosthesis* ; Blood Vessel Prosthesis* ; Elasticity/drug effects ; Female ; Losartan/pharmacology* ; Rats, Sprague-Dawley ; Tissue Scaffolds/chemistry ; Transplantation, Homologous
Keywords
Losartan ; Medial elastic fiber integrity ; Small diameter vascular conduits
Abstract
Decellularization is a proposed method of preparing nonautologous biological arterial vascular scaffolding; however, the fate of the supporting medial elastic fiber, which is important in preserving the vascular structural integrity, is uncertain. The influence of losartan on preserving the medial elastic fiber integrity in decellularized small diameter vascular conduits (SDVC) was investigated. Decellularized infrarenal abdominal aortic allografts were implanted in Sprague-Dawley rats treated either with (study rats, n = 6) or without oral losartan (control rats, n = 6) and graded 8 weeks later according to a remodeling scoring system (1-mild, 2-moderate, 3-severe) which we devised based on the intimal hyperplasia degree, morphologic changes, and elastic fiber fragmentation of the conduits. DAPI immunohistochemistry analysis was performed in 47 (25 decellularization only and 22 losartan treatment) cross-sectional slide specimens. The losartan versus decellularization only SDVC showed a significantly lower medial elastic fragmentation score (1.32 vs. 2.24, P < 0.001), superior medial layer preservation, and relatively more normal appearing intimal cellular morphology. The results suggested rats receiving decellularized SDVCs treated with losartan may yield superior medial layer elastic fiber preservation.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1111/aor.12686
DOI
10.1111/aor.12686
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
이승현(Lee, Seung Hyun) ORCID logo https://orcid.org/0000-0002-0311-6565
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165617
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