Cited 17 times in
Role of Adjuvant Chemotherapy in ypT0-2N0 Patients Treated with Preoperative Chemoradiation Therapy and Radical Resection for Rectal Cancer
DC Field | Value | Language |
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dc.contributor.author | 김남규 | - |
dc.date.accessioned | 2018-11-19T16:41:58Z | - |
dc.date.available | 2018-11-19T16:41:58Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0360-3016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165603 | - |
dc.description.abstract | OBJECTIVE: To explore the role of adjuvant chemotherapy for patients with ypT0-2N0 rectal cancer treated by preoperative chemoradiation therapy (PCRT) and radical resection. PATIENTS AND METHODS: A national consortium of 10 institutions was formed, and patients with ypT0-2N0 mid- and low-rectal cancer after PCRT and radical resection from 2004 to 2009 were included. Patients were categorized into 2 groups according to receipt of additional adjuvant chemotherapy: Adj CTx (+) versus Adj CTx (-). Propensity scores were calculated and used to perform matched and adjusted analyses comparing relapse-free survival (RFS) between treatment groups while controlling for potential confounding. RESULTS: A total of 1016 patients, who met the selection criteria, were evaluated. Of these, 106 (10.4%) did not receive adjuvant chemotherapy. There was no overall improvement in 5-year RFS as a result of adjuvant chemotherapy [91.6% for Adj CTx (+) vs 87.5% for Adj CTx (-), P=.18]. There were no differences in 5-year local recurrence and distant metastasis rate between the 2 groups. In patients who show moderate, minimal, or no regression in tumor regression grade, however, possible association of adjuvant chemotherapy with RFS would be considered (hazard ratio 0.35; 95% confidence interval 0.14-0.88; P=.03). Cox regression analysis after propensity score matching failed to show that addition of adjuvant chemotherapy was associated with improved RFS (hazard ratio 0.81; 95% confidence interval 0.39-1.70; P=.58). CONCLUSIONS: Adjuvant chemotherapy seemed to not influence the RFS of patients with ypT0-2N0 rectal cancer after PCRT followed by radical resection. Thus, the addition of adjuvant chemotherapy needs to be weighed against its oncologic benefits. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science Inc. | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/mortality | - |
dc.subject.MESH | Adenocarcinoma/pathology* | - |
dc.subject.MESH | Adenocarcinoma/secondary | - |
dc.subject.MESH | Adenocarcinoma/surgery | - |
dc.subject.MESH | Adenocarcinoma/therapy* | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Anal Canal | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/therapeutic use* | - |
dc.subject.MESH | Capecitabine | - |
dc.subject.MESH | Chemoradiotherapy, Adjuvant* | - |
dc.subject.MESH | Chemotherapy, Adjuvant | - |
dc.subject.MESH | Confidence Intervals | - |
dc.subject.MESH | Deoxycytidine/administration & dosage | - |
dc.subject.MESH | Deoxycytidine/analogs & derivatives | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorouracil/administration & dosage | - |
dc.subject.MESH | Fluorouracil/analogs & derivatives | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Recurrence, Local | - |
dc.subject.MESH | Organ Sparing Treatments | - |
dc.subject.MESH | Preoperative Care | - |
dc.subject.MESH | Propensity Score | - |
dc.subject.MESH | Radiotherapy Dosage | - |
dc.subject.MESH | Rectal Neoplasms/mortality | - |
dc.subject.MESH | Rectal Neoplasms/pathology* | - |
dc.subject.MESH | Rectal Neoplasms/surgery | - |
dc.subject.MESH | Rectal Neoplasms/therapy* | - |
dc.subject.MESH | Regression Analysis | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Role of Adjuvant Chemotherapy in ypT0-2N0 Patients Treated with Preoperative Chemoradiation Therapy and Radical Resection for Rectal Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | In Ja Park | - |
dc.contributor.googleauthor | Dae Yong Kim | - |
dc.contributor.googleauthor | Hee Cheol Kim | - |
dc.contributor.googleauthor | Nam Kyu Kim | - |
dc.contributor.googleauthor | Hyeong-Rok Kim | - |
dc.contributor.googleauthor | Sung-Bum Kang | - |
dc.contributor.googleauthor | Gyu-Seog Choi | - |
dc.contributor.googleauthor | Kang Young Lee | - |
dc.contributor.googleauthor | Seon-Hahn Kim | - |
dc.contributor.googleauthor | Seung Taek Oh | - |
dc.contributor.googleauthor | Seok-Byung Lim | - |
dc.contributor.googleauthor | Jin Cheon Kim | - |
dc.contributor.googleauthor | Jae Hwan Oh | - |
dc.contributor.googleauthor | Sun Young Kim | - |
dc.contributor.googleauthor | Woo Yong Lee | - |
dc.contributor.googleauthor | Jung Bok Lee | - |
dc.contributor.googleauthor | Chang Sik Yu | - |
dc.identifier.doi | 10.1016/j.ijrobp.2015.02.020 | - |
dc.contributor.localId | A00353 | - |
dc.relation.journalcode | J01157 | - |
dc.identifier.eissn | 1879-355X | - |
dc.identifier.pmid | 26068489 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0360301615001984 | - |
dc.contributor.alternativeName | Kim, Nam Kyu | - |
dc.contributor.affiliatedAuthor | 김남규 | - |
dc.citation.volume | 92 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 540 | - |
dc.citation.endPage | 547 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.92(3) : 540-547, 2015 | - |
dc.identifier.rimsid | 59232 | - |
dc.type.rims | ART | - |
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