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Protective Effect of Metformin Against Thyroid Cancer Development: A Population-Based Study in Korea.

DC Field Value Language
dc.contributor.author이병완-
dc.contributor.author이용호-
dc.date.accessioned2018-11-16T16:58:17Z-
dc.date.available2018-11-16T16:58:17Z-
dc.date.issued2018-
dc.identifier.issn1050-7256-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/165528-
dc.description.abstractBACKGROUND: Metformin, the most widely used drug for type 2 diabetes, has recently attracted attention with regard to its antitumor activity. However, clinical studies have yielded conflicting results regarding the association between metformin and thyroid cancer development, despite its antitumor effect in preclinical studies. METHODS: This is a retrospective cohort study using the Korean National Health Insurance claim database. Matched populations of 128,453 metformin users and 128,453 non-users were analyzed for thyroid cancer incidence. Metformin users were categorized into lowest, middle, and highest tertiles according to cumulative dose or duration of metformin therapy. RESULTS: Thyroid cancer developed in 340 (0.26%) metformin users and 487 (0.38%) non-users during a mean follow-up of 7.2 years (hazard ratio = 0.69 [confidence interval 0.60-0.79]; p < 0.001). The incidence of thyroid cancer per 105 person-years was 51.6 in metformin non-users. For metformin users, the incidence was 84.5 for <529,000 mg, 20.6 for 529,000-1,007,799 mg, and 6.3 for >1,007,799 mg; 86.3 for <1085 days, 20.3 for 1085-2094 days, and 4.7 for >2094 days for duration of therapy. The hazard ratio for thyroid cancer decreased significantly in metformin users as a function of dose and duration of metformin therapy. CONCLUSIONS: Metformin appears to be associated with a preventive effect on thyroid cancer development in a nationwide population-based study, but is not effective in the early phase of treatment. Considering the increasing prevalence of obesity and the role of insulin resistance in the development of cancer, metformin might be the preferred treatment for its dual anti-diabetic and antitumor effects.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherMary Ann Liebert Publishers-
dc.relation.isPartOfTHYROID-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleProtective Effect of Metformin Against Thyroid Cancer Development: A Population-Based Study in Korea.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorYoon Young Cho-
dc.contributor.googleauthorMin Jin Kang-
dc.contributor.googleauthorSoo Kyoung Kim-
dc.contributor.googleauthorJung Hwa Jung-
dc.contributor.googleauthorJong Ryeal Hahm-
dc.contributor.googleauthorTae Hyuk Kim-
dc.contributor.googleauthorJoo Young Nam-
dc.contributor.googleauthorByung-Wan Lee-
dc.contributor.googleauthorYong-ho Lee-
dc.contributor.googleauthorJae Hoon Chung-
dc.contributor.googleauthorSun Ok Song-
dc.contributor.googleauthorSun Wook Kim-
dc.identifier.doi10.1089/thy.2017.0550-
dc.contributor.localIdA02796-
dc.contributor.localIdA02989-
dc.relation.journalcodeJ02729-
dc.identifier.eissn1557-9077-
dc.identifier.pmid29808777-
dc.subject.keywordmetformin-
dc.subject.keywordpopulation-based study-
dc.subject.keywordprotective effect-
dc.subject.keywordthyroid cancer-
dc.contributor.alternativeNameLee, Byung Wan-
dc.contributor.alternativeNameLee, Yong Ho-
dc.contributor.affiliatedAuthor이병완-
dc.contributor.affiliatedAuthor이용호-
dc.citation.volume28-
dc.citation.number7-
dc.citation.startPage864-
dc.citation.endPage870-
dc.identifier.bibliographicCitationTHYROID, Vol.28(7) : 864-870, 2018-
dc.identifier.rimsid59139-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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