Cited 6 times in
Effects of age and comorbidity on survival vary according to risk grouping among patients with prostate cancer treated using radical prostatectomy: A retrospective competing-risk analysis from the K-CaP registry.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 구교철 | - |
dc.contributor.author | 나군호 | - |
dc.contributor.author | 이광석 | - |
dc.contributor.author | 이승환 | - |
dc.contributor.author | 정병하 | - |
dc.contributor.author | 하윤수 | - |
dc.date.accessioned | 2018-11-16T16:56:22Z | - |
dc.date.available | 2018-11-16T16:56:22Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165496 | - |
dc.description.abstract | A multicenter Korean Prostate Cancer Database (K-CaP) has been established to provide information regarding Korean patients with prostate cancer (PCa). We used the K-CaP registry to investigate the value of age and comorbidity for predicting cancer-specific mortality (CSM) and other-cause mortality (OCM) according to risk grouping.The K-CaP registry includes 2253 patients who underwent radical prostatectomy (RP) between May 2001 and April 2013 at 5 institutions. Preoperative clinicopathologic data were collected and stratified according to the National Comprehensive Cancer Network risk criteria. Survival was evaluated using Gray's modified log-rank test according to risk category, age (<70 years vs ≥70 years), and Charlson comorbidity index (CCI) (0 vs ≥1).The median follow-up was 55.0 months (interquartile range: 42.0-70.0 months). Competing-risk regression analysis revealed that, independent of CCI, ≥70-year-old high-risk patients had significantly greater CSM than <70-year-old high-risk patients (P = .019). However, <70-year-old high-risk patients with a CCI of ≥1 had similar CSM relative to ≥70-year-old patients. Survival was not affected by age or CCI among low-risk or intermediate-risk patients. Multivariate analysis revealed that a CCI of ≥1 was independently associated with a higher risk of CSM (P = .003), while an age of ≥70 years was independently associated with a higher risk of OCM (P = .005).Age and comorbidity were associated with survival after RP among patients with high-risk PCa, although these associations were not observed among low-risk or intermediate-risk patients. Therefore, older patients with high-risk diseases and greater comorbidity may require alternative multidisciplinary treatment. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Age Factors* | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Comorbidity | - |
dc.subject.MESH | Databases, Factual | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Prostatectomy/methods | - |
dc.subject.MESH | Prostatectomy/mortality* | - |
dc.subject.MESH | Prostatic Neoplasms/etiology | - |
dc.subject.MESH | Prostatic Neoplasms/mortality* | - |
dc.subject.MESH | Prostatic Neoplasms/surgery | - |
dc.subject.MESH | Registries | - |
dc.subject.MESH | Regression Analysis | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Assessment/statistics & numerical data* | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Survival Analysis | - |
dc.title | Effects of age and comorbidity on survival vary according to risk grouping among patients with prostate cancer treated using radical prostatectomy: A retrospective competing-risk analysis from the K-CaP registry. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨의학교실) | - |
dc.contributor.googleauthor | Yoon Soo Hah | - |
dc.contributor.googleauthor | Kwang Suk Lee | - |
dc.contributor.googleauthor | In Young Choi | - |
dc.contributor.googleauthor | Ji Youl Lee | - |
dc.contributor.googleauthor | Jun Hyuk Hong | - |
dc.contributor.googleauthor | Choung-Soo Kim | - |
dc.contributor.googleauthor | Hyun Moo Lee | - |
dc.contributor.googleauthor | Sung Kyu Hong | - |
dc.contributor.googleauthor | Seok-Soo Byun | - |
dc.contributor.googleauthor | Seung Hwan Lee | - |
dc.contributor.googleauthor | Koon Ho Rha | - |
dc.contributor.googleauthor | Byung Ha Chung | - |
dc.contributor.googleauthor | Kyo Chul Koo | - |
dc.identifier.doi | 10.1097/MD.0000000000012766 | - |
dc.contributor.localId | A00188 | - |
dc.contributor.localId | A01227 | - |
dc.contributor.localId | A02668 | - |
dc.contributor.localId | A02938 | - |
dc.contributor.localId | A03607 | - |
dc.contributor.localId | A05526 | - |
dc.relation.journalcode | J02214 | - |
dc.identifier.eissn | 1536-5964 | - |
dc.identifier.pmid | 30334964 | - |
dc.subject.keyword | comorbidity | - |
dc.subject.keyword | prognosis | - |
dc.subject.keyword | prostatic neoplasm | - |
dc.subject.keyword | survival | - |
dc.contributor.alternativeName | Koo, Kyo Chul | - |
dc.contributor.alternativeName | Rha, Koon Ho | - |
dc.contributor.alternativeName | Lee, Kwang Suk | - |
dc.contributor.alternativeName | Lee, Seung Hwan | - |
dc.contributor.alternativeName | Chung, Byung Ha | - |
dc.contributor.alternativeName | Ha, Yoon Soo | - |
dc.contributor.affiliatedAuthor | 구교철 | - |
dc.contributor.affiliatedAuthor | 나군호 | - |
dc.contributor.affiliatedAuthor | 이광석 | - |
dc.contributor.affiliatedAuthor | 이승환 | - |
dc.contributor.affiliatedAuthor | 정병하 | - |
dc.contributor.affiliatedAuthor | 하윤수 | - |
dc.citation.volume | 97 | - |
dc.citation.number | 42 | - |
dc.citation.startPage | e12766 | - |
dc.identifier.bibliographicCitation | MEDICINE, Vol.97(42) : e12766, 2018 | - |
dc.identifier.rimsid | 59107 | - |
dc.type.rims | ART | - |
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