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Assessment of human placenta as an ex-vivo vascular model for testing of liquid embolic agent injections with adjunctive techniques.

Authors
 Hideo Okada  ;  Joonho Chung  ;  Daniel M Heiferman  ;  Demetrius K Lopes 
Citation
 Journal of Neurointerventional Surgery, Vol.10(9) : 892-895, 2018 
Journal Title
 Journal of Neurointerventional Surgery 
ISSN
 1759-8478 
Issue Date
2018
MeSH
Balloon Embolectomy/methods* ; Dimethyl Sulfoxide/administration & dosage* ; Embolization, Therapeutic/methods* ; Female ; Fluoroscopy/methods ; Humans ; Injections ; Placenta/blood supply ; Placenta/diagnostic imaging* ; Placenta/drug effects* ; Polyvinyls/administration & dosage* ; Pregnancy
Keywords
balloon ; liquid embolic material ; technique
Abstract
PURPOSE: This project sought to test the utility of post-delivery human placenta (HP) as a vascular model for liquid embolic agent (LEA) simulation, along with adjunctive techniques. MATERIALS AND METHODS: Twelve LEA injections were performed under fluoroscopy in HP with two reflux control methods: dual lumen 'mini' balloon-catheter (n=9); and injection after proximal nBCA plug formation through a second microcatheter ('pressure cooker') (n=3). Measured outcomes included liquid embolic agent (LEA) advancement and reflux. Reflux was categorized into three grades: grade 0=no reflux; grade 1=occlusion of side branches without reflux beyond the balloon or plug; and grade 2=reflux beyond the balloon or plug. RESULTS: Simulation success was greater when a balloon was used rather than with a nBCA plug (89% vs 33%, P=0.054). In eight successful balloon-assisted injections, the reflux grades were: 50% grade 0; 12.5% grade 1; and 37.5% grade 2. The one successful nBCA plug injection had grade 2 reflux. All grade 2 balloon injections occurred when the balloon was positioned across a vessel bifurcation. CONCLUSIONS: HP provides excellent simulation for liquid embolic agents with a dual lumen balloon catheter.
Full Text
https://jnis.bmj.com/content/10/9/892.long
DOI
10.1136/neurintsurg-2017-013474
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
정준호(Chung, Joon Ho)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165482
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