Cited 8 times in
Effect of Growth Hormone Therapy on Height Velocity in Korean Children with Idiopathic Short Stature: A Phase III Randomised Controlled Trial
DC Field | Value | Language |
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dc.contributor.author | 김호성 | - |
dc.date.accessioned | 2018-11-16T16:55:13Z | - |
dc.date.available | 2018-11-16T16:55:13Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1663-2818 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165473 | - |
dc.description.abstract | BACKGROUND/AIMS: The SYNERGY (Saizen® for Your New Life and Brighter Tomorrow without Growth Deficiency) study is the first randomised multi-centre, open-label study to assess the short-term efficacy and safety of this recombinant human growth hormone (r-hGH) preparation for prepubertal children with idiopathic short stature in South Korea. METHODS: The SYNERGY study (ClinicalTrials.gov NCT01746862) was conducted at 9 centres throughout South Korea between December 2012 and March 2015. The primary endpoint was difference in height velocity from baseline to 6 months in the treatment and control arms. RESULTS: 97 children were screened; 90 were randomly assigned: 60 children to 0.067 mg/kg/day r-hGH for 12 months (treatment) and 30 children to 6 months of no treatment followed by 0.067 mg/kg/day r-hGH for 6 months (control). The 6-month mean height velocity in the treatment group increased from 5.63 cm/year (SD 1.62) to 10.08 cm/year (SD 1.92) (p < 0.0001) and from 4.94 cm/year (SD 1.91) to 5.92 cm/year (SD 2.01) (p = 0.0938) in the control group (between-group difference 3.47 cm/year, 95% CI 2.17-4.78; p < 0.0001). Adherence was > 90% throughout the study. The safety profile was consistent with that already known for r-hGH. CONCLUSION: Treatment with r-hGH in the SYNERGY study demonstrated a statistically significant increase in height velocity at 6 months | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Karger | - |
dc.relation.isPartOf | HORMONE RESEARCH IN PAEDIATRICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Effect of Growth Hormone Therapy on Height Velocity in Korean Children with Idiopathic Short Stature: A Phase III Randomised Controlled Trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아청소년과학교실) | - |
dc.contributor.googleauthor | Woo Yeong Chung | - |
dc.contributor.googleauthor | Han-Wook Yoo | - |
dc.contributor.googleauthor | Jin Soon Hwang | - |
dc.contributor.googleauthor | Cheol Woo Ko | - |
dc.contributor.googleauthor | Ho-Seong Kim | - |
dc.contributor.googleauthor | Dong-Kyu Jin | - |
dc.contributor.googleauthor | Kee-Hyoung Lee | - |
dc.contributor.googleauthor | Heon-Seok Han | - |
dc.contributor.googleauthor | Premila Paranchothy | - |
dc.contributor.googleauthor | Byung-Kyu Suh | - |
dc.identifier.doi | 10.1159/000491016 | - |
dc.contributor.localId | A01184 | - |
dc.relation.journalcode | J03514 | - |
dc.identifier.eissn | 1663-2826 | - |
dc.identifier.pmid | 30110706 | - |
dc.identifier.url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214610/ | - |
dc.identifier.url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214610/ | - |
dc.subject.keyword | Efficacy | - |
dc.subject.keyword | Height velocity | - |
dc.subject.keyword | Idiopathic short stature | - |
dc.subject.keyword | Recombinant human growth hormone | - |
dc.subject.keyword | Safety | - |
dc.contributor.alternativeName | Kim, Ho Seong | - |
dc.contributor.affiliatedAuthor | 김호성 | - |
dc.citation.volume | 90 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 44 | - |
dc.citation.endPage | 53 | - |
dc.identifier.bibliographicCitation | HORMONE RESEARCH IN PAEDIATRICS, Vol.90(1) : 44-53, 2018 | - |
dc.identifier.rimsid | 58937 | - |
dc.type.rims | ART | - |
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