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Amyloid-β-related and unrelated cortical thinning in dementia with Lewy bodies.

 Young-gun Lee  ;  Seun Jeon  ;  Han Soo Yoo  ;  Seok Jong Chung  ;  Seung-Koo Lee  ;  Phil Hyu Lee  ;  Young Ho Sohn  ;  Mijin Yun  ;  Alan C. Evans  ;  Byoung Seok 
 Neurobiology of Aging, Vol.72 : 32-39, 2018 
Journal Title
 Neurobiology of Aging 
Issue Date
Amyloid imaging ; Amyloid-beta ; Brain atrophy ; Dementia with Lewy bodies
Coexisting Alzheimer's disease (AD) pathology is common in patients with dementia with Lewy bodies (DLB). To evaluate the cortical thinning in patients with DLB considering the effect of amyloid-β (Aβ), we compared the regional cortical thickness between control subjects and patients with DLB with abnormal dopamine transporter imaging. Seventeen (43.6%) of 39 patients with DLB and no control subjects had significant Aβ deposition on 18F-florbetaben positron emission tomography. Compared to control (n = 15), Aβ-negative DLB group (n = 21) had cortical thinning in the bilateral insula, entorhinal, basal frontal, and occipito-parietal cortices. Compared to Aβ-negative DLB, Aβ-positive DLB group (n = 15) had a lower cortical thickness in the AD-prone brain regions in addition to the bilateral occipital, basal frontal, and somatomotor cortices. After controlling for the amount of Aβ deposition, DLB group had cortical thinning in the same regions affected in the Aβ-negative DLB group. In summary, patients with DLB had an Aβ-independent cortical thinning, while Aβ was associated with additional cortical thinning in the AD-prone brain regions and the aggravation of DLB-specific cortical thinning.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
손영호(Sohn, Young Ho) ORCID logo https://orcid.org/0000-0001-6533-2610
예병석(Ye, Byoung Seok) ORCID logo https://orcid.org/0000-0003-0187-8440
유한수(Yoo, Han Soo) ORCID logo https://orcid.org/0000-0001-7846-6271
윤미진(Yun, Mi Jin) ORCID logo https://orcid.org/0000-0002-1712-163X
이승구(Lee, Seung Koo) ORCID logo https://orcid.org/0000-0001-5646-4072
이필휴(Lee, Phil Hyu) ORCID logo https://orcid.org/0000-0001-9931-8462
정석종(Chung, Seok Jong) ORCID logo https://orcid.org/0000-0001-6086-3199
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