Cited 2 times in
Reconsideration of sample size and power calculation for overall survival in cancer clinical trials
DC Field | Value | Language |
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dc.contributor.author | 남정모 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 정인경 | - |
dc.date.accessioned | 2018-11-16T16:52:01Z | - |
dc.date.available | 2018-11-16T16:52:01Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165407 | - |
dc.description.abstract | When designing a cancer clinical trial, it is usual to assume an exponential distribution for a time-to-event outcome such as overall survival (OS). OS is often expressed as the sum of progression-free survival (PFS) and survival post-progression (SPP), each of which is assumed to be exponentially distributed. Then, OS does not follow an exponential distribution any more but a gamma or hypo-exponential distribution. In this study, we derived a sample size calculation formula for comparing OS between two treatment arms using the log-rank test for OS following a gamma or hypo-exponential distribution. We conducted a simulation study to evaluate the sample size and power calculation based on the gamma or hypo-exponential distribution. We found that we could reduce the sample sizes considerably compared to when assuming an exponential distribution for OS. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Reconsideration of sample size and power calculation for overall survival in cancer clinical trials | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine and Public Health (예방의학교실) | - |
dc.contributor.googleauthor | Inkyung Jung | - |
dc.contributor.googleauthor | Hee Jung Ko | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.contributor.googleauthor | Chung Mo Nam | - |
dc.identifier.doi | 10.1016/j.conctc.2018.09.007 | - |
dc.contributor.localId | A01264 | - |
dc.contributor.localId | A01316 | - |
dc.contributor.localId | A03693 | - |
dc.relation.journalcode | J03506 | - |
dc.identifier.eissn | 2451-8654 | - |
dc.identifier.pmid | 30302417 | - |
dc.subject.keyword | Hypo-exponential distribution | - |
dc.subject.keyword | Progression-free survival (PFS) | - |
dc.subject.keyword | Survival post-progression (SPP) | - |
dc.contributor.alternativeName | Nam, Jung Mo | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Jung, In Kyung | - |
dc.contributor.affiliatedAuthor | 남정모 | - |
dc.contributor.affiliatedAuthor | 라선영 | - |
dc.contributor.affiliatedAuthor | 정인경 | - |
dc.citation.volume | 12 | - |
dc.citation.startPage | 90 | - |
dc.citation.endPage | 91 | - |
dc.identifier.bibliographicCitation | CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS, Vol.12 : 90-91, 2018 | - |
dc.identifier.rimsid | 58872 | - |
dc.type.rims | ART | - |
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