Cited 23 times in
Which Patients with Isolated Para-aortic Lymph Node Metastasis Will Truly Benefit from Extended Lymph Node Dissection for Colon Cancer?
DC Field | Value | Language |
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dc.contributor.author | 김남규 | - |
dc.contributor.author | 민병소 | - |
dc.contributor.author | 백승혁 | - |
dc.contributor.author | 이강영 | - |
dc.contributor.author | 허혁 | - |
dc.date.accessioned | 2018-11-16T16:49:29Z | - |
dc.date.available | 2018-11-16T16:49:29Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165364 | - |
dc.description.abstract | Purpose: The prognosis of patientswith colon cancer and para-aortic lymph node metastasis (PALNM) is poor. We analyzed the prognostic factors of extramesenteric lymphadenectomy for colon cancer patients with isolated PALNM. Materials and Methods: We retrospectively reviewed 49 patients with PALNM who underwent curative resection between October 1988 and December 2009. Results: In univariate analyses, the 5-year overall survival (OS) and disease-free survival (DFS) rates were higher in patients with ≤ 7 positive para-aortic lymph node (PALN) (36.5% and 27.5%) than in those with > 7 PALN (14.3% and 14.3%; p=0.010 and p=0.027, respectively), and preoperative carcinoembryonic antigen (CEA) level > 5 was also correlated with a lower 5-year OS and DFS rate of 21.5% and 11.7% compared with those with CEA ≤ 5 (46.3% and 41.4%; p=0.122 and 0.039, respectively). Multivariate analysis found that the number of positive PALN (hazard ratio [HR], 3.291; 95% confidence interval [CI], 1.309 to 8.275; p=0.011) was an independent prognostic factor for OS and the number of positive PALN (HR, 2.484; 95% CI, 0.993 to 6.211; p=0.052) and preoperative CEA level (HR, 1.953; 95% CI, 0.940 to 4.057; p=0.073) were marginally independent prognostic factors for DFS. According to our prognostic model, the 5-year OS and DFS rate increased to 59.3% and 53.3%, respectively, in patients with ≤ 7 positive PALN and CEA level ≤ 5. Conclusion: PALN dissection might be beneficial in carefully selected patients with a low CEA level and less extensive PALNM | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English, Korean | - |
dc.publisher | Official journal of Korean Cancer Association | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aorta, Abdominal | - |
dc.subject.MESH | Carcinoembryonic Antigen/metabolism | - |
dc.subject.MESH | Colonic Neoplasms/metabolism | - |
dc.subject.MESH | Colonic Neoplasms/surgery* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymph Node Excision/methods* | - |
dc.subject.MESH | Lymph Nodes/surgery* | - |
dc.subject.MESH | Lymphatic Metastasis | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Survival Rate | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Which Patients with Isolated Para-aortic Lymph Node Metastasis Will Truly Benefit from Extended Lymph Node Dissection for Colon Cancer? | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Sung Uk Bae | - |
dc.contributor.googleauthor | Hyuk Hur | - |
dc.contributor.googleauthor | Byung Soh Min | - |
dc.contributor.googleauthor | Seung Hyuk Baik | - |
dc.contributor.googleauthor | Kang Young Lee | - |
dc.contributor.googleauthor | Nam Kyu Kim | - |
dc.identifier.doi | 10.4143/crt.2017.100 | - |
dc.contributor.localId | A00353 | - |
dc.contributor.localId | A01402 | - |
dc.contributor.localId | A01827 | - |
dc.contributor.localId | A02640 | - |
dc.contributor.localId | A04373 | - |
dc.relation.journalcode | J00453 | - |
dc.identifier.eissn | 2005-9256 | - |
dc.identifier.pmid | 28707461 | - |
dc.subject.keyword | Lymph node excision | - |
dc.subject.keyword | Lymph nodes | - |
dc.subject.keyword | Lymphatic metastasis | - |
dc.subject.keyword | Colonic neoplasms | - |
dc.contributor.alternativeName | Kim, Nam Kyu | - |
dc.contributor.alternativeName | Min, Byung Soh | - |
dc.contributor.alternativeName | Baik, Seung Hyuk | - |
dc.contributor.alternativeName | Lee, Kang Young | - |
dc.contributor.alternativeName | Hur, Hyuk | - |
dc.contributor.affiliatedAuthor | 김남규 | - |
dc.contributor.affiliatedAuthor | 민병소 | - |
dc.contributor.affiliatedAuthor | 백승혁 | - |
dc.contributor.affiliatedAuthor | 이강영 | - |
dc.contributor.affiliatedAuthor | 허혁 | - |
dc.citation.volume | 50 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 712 | - |
dc.citation.endPage | 719 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, Vol.50(3) : 712-719, 2018 | - |
dc.identifier.rimsid | 58776 | - |
dc.type.rims | ART | - |
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