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The Prognostic Impact of the Number of Metastatic Lymph Nodes and a New Prognostic Scoring System for Recurrence in Early-Stage Cervical Cancer with High Risk Factors: A Multicenter Cohort Study (KROG 15-04).

DC FieldValueLanguage
dc.contributor.author김용배-
dc.date.accessioned2018-11-16T16:46:40Z-
dc.date.available2018-11-16T16:46:40Z-
dc.date.issued2018-
dc.identifier.issn1598-2998-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/165313-
dc.description.abstractPurpose: We aimed to assess prognostic value of metastatic pelvic lymph node (mPLN) in early-stage cervical cancer treated with radical surgery followed by postoperative chemoradiotherapy. Also, we sought to define a high-risk group using prognosticators for recurrence. Materials and Methods: A multicenter retrospective study was conducted using the data from 13 Korean institutions from 2000 to 2010. A total of 249 IB-IIA patients with high-risk factors were included. We evaluated distant metastasis-free survival (DMFS) and disease-free survival (DFS) in relation to clinicopathologic factors including pNstage, number of mPLN, lymph node (LN)ratio (number of positive LN/number of harvested LN), and log odds of mPLNs (log(number of positive LN+0.5/number of negative LN+0.5)). Results: In univariate analysis, histology (squamous cell carcinoma [SqCC] vs. others), lymphovascular invasion (LVI), number of mPLNs (≤ 3 vs. > 3), LN ratio (≤ 17% vs. > 17%), and log odds of mPLNs (≤ ‒0.58 vs. > ‒0.58) were significant prognosticators for DMFS and DFS. Resection margin involvement only affected DFS. No significant survival difference was observed between pN0 patients and patients with 1-3 mPLNs. Multivariate analysis revealed that mPLN > 3, LVI, and non-SqCC were unfavorable index for both DMFS (p < 0.001, p=0.020, and p=0.031, respectively) and DFS (p < 0.001, p=0.017, and p=0.001, respectively). A scoring system using these three factors predicts risk of recurrence with relatively high concordance index (DMFS, 0.69; DFS, 0.71). Conclusion: mPLN > 3 in early-stage cervical cancer affects DMFS and DFS. A scoring system using mPLNs > 3, LVI, and non-SqCC could stratify risk groups of recurrence in surgically resected early-stage cervix cancer with high-risk factors.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish, Korean-
dc.publisherOfficial journal of Korean Cancer Association-
dc.relation.isPartOfCANCER RESEARCH AND TREATMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCarcinoma, Squamous Cell/pathology*-
dc.subject.MESHCarcinoma, Squamous Cell/therapy*-
dc.subject.MESHChemoradiotherapy, Adjuvant-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHysterectomy-
dc.subject.MESHLymph Nodes/pathology*-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Recurrence, Local/pathology*-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPelvis-
dc.subject.MESHPrognosis-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHUterine Cervical Neoplasms/pathology*-
dc.subject.MESHUterine Cervical Neoplasms/therapy*-
dc.titleThe Prognostic Impact of the Number of Metastatic Lymph Nodes and a New Prognostic Scoring System for Recurrence in Early-Stage Cervical Cancer with High Risk Factors: A Multicenter Cohort Study (KROG 15-04).-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.googleauthorJeanny Kwon-
dc.contributor.googleauthorKeun-Young Eom-
dc.contributor.googleauthorYoung Seok Kim-
dc.contributor.googleauthorWon Park-
dc.contributor.googleauthorMison Chun-
dc.contributor.googleauthorJihae Lee-
dc.contributor.googleauthorYong Bae Kim-
dc.contributor.googleauthorWon Sup Yoon-
dc.contributor.googleauthorJin Hee Kim-
dc.contributor.googleauthorJin Hwa Choi-
dc.contributor.googleauthorSei Kyung Chang-
dc.contributor.googleauthorBae Kwon Jeong-
dc.contributor.googleauthorSeok Ho Lee-
dc.contributor.googleauthorJihye Cha-
dc.identifier.doi10.4143/crt.2017.346-
dc.contributor.localIdA00744-
dc.contributor.localIdA00744-
dc.relation.journalcodeJ00453-
dc.identifier.eissn2005-9256-
dc.identifier.pmid29081219-
dc.subject.keywordAdjuvant treatment-
dc.subject.keywordCombined modality therapy-
dc.subject.keywordLymphatic metastasis-
dc.subject.keywordScoring system-
dc.subject.keywordUterine cervical neoplasms-
dc.contributor.alternativeNameKim, Yong Bae-
dc.contributor.affiliatedAuthor김용배-
dc.citation.volume50-
dc.citation.number3-
dc.citation.startPage964-
dc.citation.endPage974-
dc.identifier.bibliographicCitationCANCER RESEARCH AND TREATMENT, Vol.50(3) : 964-974, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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