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Preventive effect of polynucleotide on post-thyroidectomy scars: A randomized, double-blinded, controlled trial.

 Ji Hee Kim  ;  Jong Ju Jeong  ;  Young In Lee  ;  Won Jai Lee  ;  Chorok Lee  ;  Woong Youn Chung  ;  Kee‐Hyun Nam  ;  Ju Hee Lee 
 LASERS IN SURGERY AND MEDICINE, Vol.50(7) : 755-762, 2018 
Journal Title
Issue Date
post‐operative scar ; thyroidectomy ; scar ; laser
Background and Objective Polynucleotide (PN) provides a structural scaffold to induce anti‐inflammatory and enhanced wound healing properties, and this study aimed to assess the efficacy of PN administration in the prevention of post‐operative scars after conventional open total thyroidectomy. Study Design Materials and Methods Forty‐two patients with thyroid carcinoma who underwent total thyroidectomy were randomly assigned to the study (PN administration) or control (normal saline) group. All patients underwent a single session of combined ablative and non‐ablative fractional laser. The Vancouver Scar Scale (VSS), global photographic assessment, and objective scar were assessed using three‐dimensional (3D) camera at baseline and at 2, 4, 8, and 16 weeks after surgery. Results Patients who underwent PN injection demonstrated better surgical scar quality outcome. Participants in the PN administration group had lower VSS scores than the control group (2.09 ± 0.47 vs. 4.01 ± 0.55, respectively) and lower scar height (0.23 ± 0.03 vs. 0.29 ± 0.03, respectively), as measured using 3D imaging. Furthermore, in the PN injected group, the degree of erythema, and pigmentation of the scar were less prominent. No patient developed hypertrophic scar or keloids on the surgical site. No other adverse events, including post‐inflammatory hyperpigmentation, scarring, or infection, were observed. Conclusion Adjuvant administration of PN along with conventional fractional laser treatment led to more favorable effect in wound healing and post‐operative scar prevention after thyroidectomy. Lasers Surg. Med. 50:755–762, 2018. © 2018 Wiley Periodicals, Inc.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jihee(김지희) ORCID logo https://orcid.org/0000-0002-0047-5941
Nam, Kee Hyun(남기현) ORCID logo https://orcid.org/0000-0002-6852-1190
Lee, Won Jai(이원재) ORCID logo https://orcid.org/0000-0003-3056-0503
Lee, Ju Hee(이주희) ORCID logo https://orcid.org/0000-0002-1739-5956
Lee, Cho Rok(이초록) ORCID logo https://orcid.org/0000-0001-7848-3709
Chung, Woung Youn(정웅윤)
Jeong, Jong Ju(정종주) ORCID logo https://orcid.org/0000-0002-4155-6035
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