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The implications of TrkA and MET aberrations in de novo salivary duct carcinoma

DC FieldValueLanguage
dc.contributor.author고윤우-
dc.contributor.author윤선옥-
dc.date.accessioned2018-11-16T16:43:00Z-
dc.date.available2018-11-16T16:43:00Z-
dc.date.issued2018-
dc.identifier.issn0046-8177-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/165254-
dc.description.abstractSalivary duct carcinoma (SDC) is an aggressive carcinoma with poor prognosis. Although anti-HER2 therapy is a potential treatment option for HER2-positive SDC, other potential therapeutic targets are not known, in particular for HER2-negative cases. In this study, the recently identified receptor tyrosine kinases MET and tropomyosin-receptor kinase (Trk) were investigated as potential therapeutic targets. A total of 28 consecutive, surgically resected, de novo SDC cases were selected after evaluating histology and immunohistochemical expression of androgen receptor. Immunohistochemical expression of c-erb2, TrkA, TrkB, TrkC, and c-MET were analyzed, and the genetic status of the HER2 and MET genes were investigated through dual-color silver in situ hybridization. High expression of c-MET or Trk was defined as that above the median value. Among the 28 SDC cases, 64.3% (18/28) were HER2-positive. c-MET expression varied, with a median H-score of 65 (range, 0 to 200). Copy number gain and amplification of MET were noted in 57.1% (16/28) and 10.7% (3/28) of cases, respectively. TrkA was variably expressed, with a median H-score of 100 (range, 0 to250). High TrkA expression was significantly related to an inferior overall survival rate in HER2-negative SDC. High expression of TrkA and c-MET and MET copy number gain/amplification were frequent events in SDC, and high expression of TrkA revealed the tendency to be related to poor prognosis in HER2-negative SDC. TrkA and MET may be possible therapeutic targets in SDC, especially in HER2-negative SDC.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherW B Saunders-
dc.relation.isPartOfHuman Pathology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe implications of TrkA and MET aberrations in de novo salivary duct carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학교실)-
dc.contributor.googleauthorHyang Joo Ryu-
dc.contributor.googleauthorYoon Woo Koh-
dc.contributor.googleauthorSun Och Yoon-
dc.identifier.doi10.1016/j.humpath.2018.04.027-
dc.contributor.localIdA00133-
dc.contributor.localIdA00133-
dc.contributor.localIdA02566-
dc.relation.journalcodeJ01011-
dc.identifier.eissn1532-8392-
dc.identifier.pmid29753009-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0046817718301576-
dc.subject.keywordBiomarker-
dc.subject.keywordMET-
dc.subject.keywordPrognosis-
dc.subject.keywordSalivary Duct Carcinoma-
dc.subject.keywordTrk-
dc.contributor.alternativeNameKho, Yoon Woo-
dc.contributor.alternativeNameYoon, Sun Och-
dc.contributor.affiliatedAuthor고윤우-
dc.contributor.affiliatedAuthor윤선옥-
dc.citation.volume81-
dc.citation.startPage18-
dc.citation.endPage25-
dc.identifier.bibliographicCitationHuman Pathology, Vol.81 : 18-25, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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