Cited 8 times in
The implications of TrkA and MET aberrations in de novo salivary duct carcinoma
DC Field | Value | Language |
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dc.contributor.author | 고윤우 | - |
dc.contributor.author | 윤선옥 | - |
dc.date.accessioned | 2018-11-16T16:43:00Z | - |
dc.date.available | 2018-11-16T16:43:00Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0046-8177 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165254 | - |
dc.description.abstract | Salivary duct carcinoma (SDC) is an aggressive carcinoma with poor prognosis. Although anti-HER2 therapy is a potential treatment option for HER2-positive SDC, other potential therapeutic targets are not known, in particular for HER2-negative cases. In this study, the recently identified receptor tyrosine kinases MET and tropomyosin-receptor kinase (Trk) were investigated as potential therapeutic targets. A total of 28 consecutive, surgically resected, de novo SDC cases were selected after evaluating histology and immunohistochemical expression of androgen receptor. Immunohistochemical expression of c-erb2, TrkA, TrkB, TrkC, and c-MET were analyzed, and the genetic status of the HER2 and MET genes were investigated through dual-color silver in situ hybridization. High expression of c-MET or Trk was defined as that above the median value. Among the 28 SDC cases, 64.3% (18/28) were HER2-positive. c-MET expression varied, with a median H-score of 65 (range, 0 to 200). Copy number gain and amplification of MET were noted in 57.1% (16/28) and 10.7% (3/28) of cases, respectively. TrkA was variably expressed, with a median H-score of 100 (range, 0 to250). High TrkA expression was significantly related to an inferior overall survival rate in HER2-negative SDC. High expression of TrkA and c-MET and MET copy number gain/amplification were frequent events in SDC, and high expression of TrkA revealed the tendency to be related to poor prognosis in HER2-negative SDC. TrkA and MET may be possible therapeutic targets in SDC, especially in HER2-negative SDC. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | W B Saunders | - |
dc.relation.isPartOf | HUMAN PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | The implications of TrkA and MET aberrations in de novo salivary duct carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학교실) | - |
dc.contributor.googleauthor | Hyang Joo Ryu | - |
dc.contributor.googleauthor | Yoon Woo Koh | - |
dc.contributor.googleauthor | Sun Och Yoon | - |
dc.identifier.doi | 10.1016/j.humpath.2018.04.027 | - |
dc.contributor.localId | A00133 | - |
dc.contributor.localId | A02566 | - |
dc.relation.journalcode | J01011 | - |
dc.identifier.eissn | 1532-8392 | - |
dc.identifier.pmid | 29753009 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0046817718301576 | - |
dc.subject.keyword | Biomarker | - |
dc.subject.keyword | MET | - |
dc.subject.keyword | Prognosis | - |
dc.subject.keyword | Salivary Duct Carcinoma | - |
dc.subject.keyword | Trk | - |
dc.contributor.alternativeName | Kho, Yoon Woo | - |
dc.contributor.alternativeName | Yoon, Sun Och | - |
dc.contributor.affiliatedAuthor | 고윤우 | - |
dc.contributor.affiliatedAuthor | 윤선옥 | - |
dc.citation.volume | 81 | - |
dc.citation.startPage | 18 | - |
dc.citation.endPage | 25 | - |
dc.identifier.bibliographicCitation | HUMAN PATHOLOGY, Vol.81 : 18-25, 2018 | - |
dc.identifier.rimsid | 58668 | - |
dc.type.rims | ART | - |
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