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Genetic Alterations among Korean Melanoma Patients Showing Tumor Heterogeneity: A Comparison between Primary Tumors and Corresponding Metastatic Lesions.

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dc.contributor.author노미령-
dc.contributor.author라선영-
dc.contributor.author신상준-
dc.contributor.author오병호-
dc.contributor.author이시형-
dc.contributor.author정기양-
dc.date.accessioned2018-11-16T16:42:01Z-
dc.date.available2018-11-16T16:42:01Z-
dc.date.issued2018-
dc.identifier.issn1598-2998-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/165237-
dc.description.abstractPURPOSE: Melanoma is a highly heterogeneous neoplasm, composed of subpopulations of tumor cells with distinct molecular and biological phenotypes and genotypes. In this study, to determine the genetic heterogeneity between primary and metastatic melanoma in Korean melanoma patients, we evaluated several well-known genetic alterations of melanoma. In addition, to elucidate the clinical relevance of each genetic alteration and heterogeneity between primary and metastatic lesions, clinical features and patient outcome were collected. Materials and Methods: In addition to clinical data, BRAF, NRAS, GNAQ/11 mutation and KIT amplification data was acquired from an archived primary Korean melanoma cohort (KMC) of 188 patients. Among these patients, 43 patients were included for investigation of tumor heterogeneity between primary melanoma and its corresponding metastatic lesions. RESULTS: Overall incidence of genetic aberrations of the primary melanomas in KMC was 17.6% of BRAF V600, 12.6% of NRAS mutation, and 28.6% of KIT amplification. GNAQ/11 mutation was seen in 66.6% of the uveal melanoma patients. Patients with BRAF mutation were associated with advanced stage and correlated to poor prognosis (p < 0.01). Among 43 patients, 55.8% showed heterogeneity between primary and metastatic lesion. The frequency of BRAF mutation and KIT amplification significantly increased in the metastatic lesions compared to primary melanomas. <GNAQ/11 mutation showed 100% homogeneity in uveal melanoma patients. CONCLUSION: Our data demonstrated heterogeneity between primary melanomas and corresponding metastatic lesions for BRAF, NRAS mutation and KIT amplification. However, GNAQ/11 mutation was genetically homogeneous between primary and metastatic melanoma lesions in uveal melanoma.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish, Korean-
dc.publisherOfficial journal of Korean Cancer Association-
dc.relation.isPartOfCANCER RESEARCH AND TREATMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleGenetic Alterations among Korean Melanoma Patients Showing Tumor Heterogeneity: A Comparison between Primary Tumors and Corresponding Metastatic Lesions.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학교실)-
dc.contributor.googleauthorSi-Hyung Lee-
dc.contributor.googleauthorJee Eun Kim-
dc.contributor.googleauthorHong Sun Jang-
dc.contributor.googleauthorKyu Hyun Park-
dc.contributor.googleauthorByung Ho Oh-
dc.contributor.googleauthorSang Joon Shin-
dc.contributor.googleauthorKee Yang Chung-
dc.contributor.googleauthorMi Ryung Roh-
dc.contributor.googleauthorSun Young Rha-
dc.identifier.doi10.4143/crt.2017.535-
dc.contributor.localIdA01278-
dc.contributor.localIdA01316-
dc.contributor.localIdA02105-
dc.contributor.localIdA02367-
dc.contributor.localIdA04855-
dc.contributor.localIdA03582-
dc.relation.journalcodeJ00453-
dc.identifier.eissn2005-9256-
dc.identifier.pmid29361821-
dc.subject.keywordBRAF-
dc.subject.keywordHeterogeneity-
dc.subject.keywordKIT-
dc.subject.keywordMelanoma-
dc.subject.keywordNRAS-
dc.contributor.alternativeNameRoh, Mi Ryung-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNameShin, Sang Joon-
dc.contributor.alternativeNameOh, Byung Ho-
dc.contributor.alternativeNameLee, Si Hyung-
dc.contributor.alternativeNameChung, Kee Yang-
dc.contributor.affiliatedAuthor노미령-
dc.contributor.affiliatedAuthor라선영-
dc.contributor.affiliatedAuthor신상준-
dc.contributor.affiliatedAuthor오병호-
dc.contributor.affiliatedAuthor이시형-
dc.contributor.affiliatedAuthor정기양-
dc.citation.volume50-
dc.citation.number4-
dc.citation.startPage1378-
dc.citation.endPage1387-
dc.identifier.bibliographicCitationCANCER RESEARCH AND TREATMENT, Vol.50(4) : 1378-1387, 2018-
dc.identifier.rimsid58654-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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