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A Filtering Method for Identification of Significant Target mRNAs of Coexpressed and Differentially Expressed MicroRNA Clusters
DC Field | Value | Language |
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dc.contributor.author | 박유랑 | - |
dc.date.accessioned | 2018-11-16T16:41:27Z | - |
dc.date.available | 2018-11-16T16:41:27Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 2040-2295 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165227 | - |
dc.description.abstract | MicroRNA (miRNA) binding is primarily based on sequence, but structure-specific binding is also possible. Various prediction algorithms have been developed for predicting miRNA target genes; the results, however, have relatively high levels of false positives, and the degree of overlap between predicted targets from different methods is poor or null. We devised a new method for identifying significant miRNA target genes from an extensive list of predicted miRNA target gene relationships using hypergeometric distributions. We evaluated our method in statistical and semantic aspects using a common miRNA cluster from six solid tumors. Our method provides statistically and semantically significant miRNA target genes. Complementing target prediction algorithms with our proposed method may have a significant synergistic effect in finding and evaluating functional annotation and enrichment analysis for miRNA. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Hindawi Publishing | - |
dc.relation.isPartOf | JOURNAL OF HEALTHCARE ENGINEERING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | A Filtering Method for Identification of Significant Target mRNAs of Coexpressed and Differentially Expressed MicroRNA Clusters | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) | - |
dc.contributor.googleauthor | Su Yeon Lee | - |
dc.contributor.googleauthor | Soo-Yong Shin | - |
dc.contributor.googleauthor | Young Jo Yoon | - |
dc.contributor.googleauthor | Yu Rang Park | - |
dc.identifier.doi | 10.1155/2018/4932904 | - |
dc.contributor.localId | A05624 | - |
dc.relation.journalcode | J03518 | - |
dc.identifier.eissn | 2040-2309 | - |
dc.identifier.pmid | 30298100 | - |
dc.contributor.alternativeName | Park, Yu Rang | - |
dc.contributor.affiliatedAuthor | 박유랑 | - |
dc.citation.volume | 2018 | - |
dc.citation.startPage | 4932904 | - |
dc.identifier.bibliographicCitation | JOURNAL OF HEALTHCARE ENGINEERING, Vol.2018 : 4932904, 2018 | - |
dc.identifier.rimsid | 58644 | - |
dc.type.rims | ART | - |
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