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A Filtering Method for Identification of Significant Target mRNAs of Coexpressed and Differentially Expressed MicroRNA Clusters

Authors
 Su Yeon Lee  ;  Soo-Yong Shin  ;  Young Jo Yoon  ;  Yu Rang Park 
Citation
 JOURNAL OF HEALTHCARE ENGINEERING, Vol.2018 : 4932904, 2018 
Journal Title
 JOURNAL OF HEALTHCARE ENGINEERING 
ISSN
 2040-2295 
Issue Date
2018
Abstract
MicroRNA (miRNA) binding is primarily based on sequence, but structure-specific binding is also possible. Various prediction algorithms have been developed for predicting miRNA target genes; the results, however, have relatively high levels of false positives, and the degree of overlap between predicted targets from different methods is poor or null. We devised a new method for identifying significant miRNA target genes from an extensive list of predicted miRNA target gene relationships using hypergeometric distributions. We evaluated our method in statistical and semantic aspects using a common miRNA cluster from six solid tumors. Our method provides statistically and semantically significant miRNA target genes. Complementing target prediction algorithms with our proposed method may have a significant synergistic effect in finding and evaluating functional annotation and enrichment analysis for miRNA.
Files in This Item:
T201803658.pdf Download
DOI
10.1155/2018/4932904
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
Yonsei Authors
Park, Yu Rang(박유랑) ORCID logo https://orcid.org/0000-0002-4210-2094
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165227
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