Cited 43 times in
Use of sedative-hypnotics and the risk of Alzheimer's dementia: A retrospective cohort study
DC Field | Value | Language |
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dc.contributor.author | 정선재 | - |
dc.date.accessioned | 2018-11-16T16:41:26Z | - |
dc.date.available | 2018-11-16T16:41:26Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165226 | - |
dc.description.abstract | There has been a growing interest in the relationship between sedative-hypnotics use and the risk of Alzheimer's dementia (AD) risk. This study aimed to evaluate the risk of AD associated with the use of sedative-hypnotics. A retrospective cohort study was conducted with randomly selected 5% samples from ≥50 years old beneficiaries of National Health Insurance Service (NHIS) of Korea from January 2002 to December 2015. The exposure to sedative-hypnotics was defined when prescribed over 30 defined daily dose (DDD) after January 2004 and it was categorized by prescribed dosage, types and half-lives of benzodiazepines. Time-dependent Cox regression model with a lag period of 5-years was used to evaluate the association between use of sedative-hypnotics and the risk of subsequent AD. Sensitivity analysis was performed for restricting sedative-hypnotics only when prescribed with insomnia. A total of 268,170 subjects were identified and subjects exposed to sedative-hypnotics showed a higher risk of AD (HR: 1.79; 95% CI: 1.72-1.86) than those who were not. There was an increased risk of AD among subjects exposed to benzodiazepines or zolpidem (HR: 1.75; 95% CI: 1.67-1.82) and antidepressants or low-dose antipsychotics (HR: 1.63; 95% CI: 1.42-1.87). The risk of AD was increased regardless of dose of sedative-hypnotics and half-life among benzodiazepines, especially in exposure to more than 360 DDD of sedative-hypnotics (HR: 1.78; 95% CI: 1.60-1.99) and the long-acting benzodiazepine (HR:1.77; 95% CI: 1.65-1.89) | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Use of sedative-hypnotics and the risk of Alzheimer's dementia: A retrospective cohort study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine and Public Health (예방의학교실) | - |
dc.contributor.googleauthor | Joonki Lee | - |
dc.contributor.googleauthor | Sun Jae Jung | - |
dc.contributor.googleauthor | Jae-won Choi | - |
dc.contributor.googleauthor | Aesun Shin | - |
dc.contributor.googleauthor | Yu Jin Lee | - |
dc.identifier.doi | 10.1371/journal.pone.0204413 | - |
dc.contributor.localId | A05546 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 30248129 | - |
dc.contributor.alternativeName | Jung, Sun Jae | - |
dc.contributor.affiliatedAuthor | 정선재 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | e0204413 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.13(9) : e0204413, 2018 | - |
dc.identifier.rimsid | 58643 | - |
dc.type.rims | ART | - |
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