Cited 27 times in
Stabilization of Cyclin-Dependent Kinase 4 by Methionyl-tRNA Synthetase in p16INK4a-Negative Cancer
DC Field | Value | Language |
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dc.contributor.author | 이동기 | - |
dc.contributor.author | 장성일 | - |
dc.date.accessioned | 2018-11-12T16:40:44Z | - |
dc.date.available | 2018-11-12T16:40:44Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165159 | - |
dc.description.abstract | Although abnormal increases in the level or activity of cyclin-dependent kinase 4 (CDK4) occur frequently in cancer, the underlying mechanism is not fully understood. Here, we show that methionyl-tRNA synthetase (MRS) specifically stabilizes CDK4 by enhancing the formation of the complex between CDK4 and a chaperone protein. Knockdown of MRS reduced the CDK4 level, resulting in G0/G1 cell cycle arrest. The effects of MRS on CDK4 stability were more prominent in the tumor suppressor p16INK4a-negative cancer cells because of the competitive relationship of the two proteins for binding to CDK4. Suppression of MRS reduced cell transformation and the tumorigenic ability of a p16INK4a-negative breast cancer cell line in vivo. Further, the MRS levels showed a positive correlation with those of CDK4 and the downstream signals at high frequency in p16INK4a-negative human breast cancer tissues. This work revealed an unexpected functional connection between the two enzymes involving protein synthesis and the cell cycle. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Chemical Society | - |
dc.relation.isPartOf | ACS Pharmacology & Translational Science | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Stabilization of Cyclin-Dependent Kinase 4 by Methionyl-tRNA Synthetase in p16INK4a-Negative Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Nam Hoon Kwon | - |
dc.contributor.googleauthor | Jin Young Lee | - |
dc.contributor.googleauthor | Ye-lim Ryu | - |
dc.contributor.googleauthor | Chanhee Kim | - |
dc.contributor.googleauthor | Jiwon Kong | - |
dc.contributor.googleauthor | Seongeun Oh | - |
dc.contributor.googleauthor | Beom Sik Kang | - |
dc.contributor.googleauthor | Hye Won Ahn | - |
dc.contributor.googleauthor | Sung Gwe Ahn | - |
dc.contributor.googleauthor | Joon Jeong | - |
dc.contributor.googleauthor | Hoi Kyoung Kim | - |
dc.contributor.googleauthor | Jong Hyun Kim | - |
dc.contributor.googleauthor | Dae Young Han | - |
dc.contributor.googleauthor | Min Chul Park | - |
dc.contributor.googleauthor | Doyeun Kim | - |
dc.contributor.googleauthor | Ryuichi Takase | - |
dc.contributor.googleauthor | Isao Masuda | - |
dc.contributor.googleauthor | Ya-Ming Hou | - |
dc.contributor.googleauthor | Sung Ill Jang | - |
dc.contributor.googleauthor | Yoon Soo Chang | - |
dc.contributor.googleauthor | Dong Ki Lee | - |
dc.contributor.googleauthor | Youngeun Kim | - |
dc.contributor.googleauthor | Ming-Wei Wang | - |
dc.contributor.googleauthor | Basappa | - |
dc.contributor.googleauthor | Sunghoon Kim | - |
dc.identifier.doi | 10.1021/acsptsci.8b00001 | - |
dc.contributor.localId | A02723 | - |
dc.contributor.localId | A03441 | - |
dc.relation.journalcode | J03496 | - |
dc.identifier.eissn | 2575-9108 | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/acsptsci.8b00001 | - |
dc.subject.keyword | CDK4 | - |
dc.subject.keyword | cell cycle | - |
dc.subject.keyword | HSP90 | - |
dc.subject.keyword | methionyl-tRNA synthetase | - |
dc.subject.keyword | p16INK4a | - |
dc.contributor.alternativeName | Lee, Dong Ki | - |
dc.contributor.alternativeName | Jang, Sung Ill | - |
dc.contributor.affiliatedAuthor | 이동기 | - |
dc.contributor.affiliatedAuthor | 장성일 | - |
dc.citation.volume | 1 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 21 | - |
dc.citation.endPage | 31 | - |
dc.identifier.bibliographicCitation | ACS Pharmacology & Translational Science, Vol.1(1) : 21-31, 2018 | - |
dc.identifier.rimsid | 59159 | - |
dc.type.rims | ART | - |
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