Cited 4 times in
Regulatory T cell expressed MyD88 is critical for prolongation of allograft survival
DC Field | Value | Language |
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dc.contributor.author | 김범석 | - |
dc.date.accessioned | 2018-11-12T16:40:25Z | - |
dc.date.available | 2018-11-12T16:40:25Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0934-0874 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165152 | - |
dc.description.abstract | MyD88 signaling directly promotes T-cell survival and is required for optimal T-cell responses to pathogens. To examine the role of T-cell-intrinsic MyD88 signals in transplantation, we studied mice with targeted T-cell-specific MyD88 deletion. Contrary to expectations, we found that these mice were relatively resistant to prolongation of graft survival with anti-CD154 plus rapamycin in a class II-mismatched system. To specifically examine the role of MyD88 in Tregs, we created a Treg-specific MyD88-deficient mouse. Transplant studies in these animals replicated the findings observed with a global T-cell MyD88 knockout. Surprisingly, given the role of MyD88 in conventional T-cell survival, we found no defect in the survival of MyD88-deficient Tregs in vitro or in the transplant recipients and also observed intact cell homing and expression of Treg effector molecules. MyD88-deficient Tregs also fail to protect allogeneic bone marrow transplant recipients from chronic graft-versus-host disease, confirming the observations of defective regulation seen in a solid organ transplant system. Together, our data define MyD88 as having a divergent requirement for cell survival in non-Tregs and Tregs, and a yet-to-be defined survival-independent requirement for Treg function during the response to alloantigen. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Blackwell Pub. | - |
dc.relation.isPartOf | TRANSPLANT INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bone Marrow Transplantation | - |
dc.subject.MESH | CD40 Ligand/metabolism | - |
dc.subject.MESH | Cell Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Flow Cytometry | - |
dc.subject.MESH | Gene Deletion | - |
dc.subject.MESH | Graft Rejection/immunology* | - |
dc.subject.MESH | Graft Survival/immunology* | - |
dc.subject.MESH | Graft vs Host Disease* | - |
dc.subject.MESH | Heart Transplantation | - |
dc.subject.MESH | Inflammation | - |
dc.subject.MESH | Isoantigens | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Knockout | - |
dc.subject.MESH | Myeloid Differentiation Factor 88/metabolism* | - |
dc.subject.MESH | Signal Transduction | - |
dc.subject.MESH | Sirolimus/administration & dosage | - |
dc.subject.MESH | Sirolimus/metabolism | - |
dc.subject.MESH | Skin/pathology | - |
dc.subject.MESH | Skin Transplantation | - |
dc.subject.MESH | T-Lymphocytes, Regulatory/cytology* | - |
dc.subject.MESH | Transplantation, Homologous | - |
dc.title | Regulatory T cell expressed MyD88 is critical for prolongation of allograft survival | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Christopher M. Borges | - |
dc.contributor.googleauthor | Dawn K. Reichenbach | - |
dc.contributor.googleauthor | Beom Seok Kim | - |
dc.contributor.googleauthor | Aditya Misra | - |
dc.contributor.googleauthor | Bruce R. Blazar | - |
dc.contributor.googleauthor | Laurence A. Turka | - |
dc.identifier.doi | 10.1111/tri.12788 | - |
dc.contributor.localId | A00488 | - |
dc.relation.journalcode | J02753 | - |
dc.identifier.eissn | 1432-2277 | - |
dc.identifier.pmid | 27112509 | - |
dc.subject.keyword | T cells | - |
dc.subject.keyword | Treg | - |
dc.subject.keyword | inflammation | - |
dc.subject.keyword | transplantation | - |
dc.contributor.alternativeName | Kim, Beom Seok | - |
dc.contributor.affiliatedAuthor | 김범석 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 930 | - |
dc.citation.endPage | 940 | - |
dc.identifier.bibliographicCitation | TRANSPLANT INTERNATIONAL, Vol.29(8) : 930-940, 2016 | - |
dc.identifier.rimsid | 59153 | - |
dc.type.rims | ART | - |
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