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Percutaneous cryoablation for renal cell carcinoma using ultrasound-guided targeting and computed tomography-guided ice-ball monitoring: radiation dose and short-term outcomes

Authors
 Dong Kyu Kim  ;  Jong Yun Won  ;  Sung Yoon Park 
Citation
 Acta Radiologica, (epub.), 2018 
Journal Title
 Acta Radiologica 
ISSN
 0284-1851 
Issue Date
2018
Keywords
Cryoablation ; cryotherapy ; kidney ; radiation ; renal cell carcinoma
Abstract
Background Usefulness of ultrasound (US)-guided mass targeting and computed tomography (CT)-guided ice-ball monitoring in percutaneous cryoablation (PCA) for renal cell carcinoma (RCC) is still uncertain. Purpose To assess radiation dose and short-term outcomes of PCA for RCC using US-guided targeting and CT-guided ice-ball monitoring. Material and Methods Thirty-nine consecutive patients who underwent PCA for biopsy-proven RCC were included. Mass targeting was performed with US and ice-ball was monitored with CT guidance. Effective radiation dose of CT during PCA was recorded. Follow-up was conducted with contrast-enhanced CT or magnetic resonance imaging (MRI) (mean follow-up time = 10.1 ± 7.0 months). Local tumor progression was defined by the presence of focal enhancing areas at the ablation zone (CT, ≥ 20 HU; MRI, presence of focal enhancement on subtraction contrast-enhanced image). Technical success, major complication rate (e.g. Clavien-Dindo classification ≥ 3), and one-year local tumor progression-free survival (PFS) rate were analyzed. Results Mean effective radiation dose in association with PCA was 12.1 ± 4.5 mSv (range = 7.0-25.2 mSv). Technical success was achieved in 100%. Local tumor progression occurred in a single patient (2.6%, 1/39), and one-year local tumor PFS rate was 95.7%. No major complication was found. Conclusion PCA using US-guided targeting and CT-guided ice-ball monitoring may allow acceptable local tumor control for RCC, as a radiation-reducing strategy.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165123
Full Text
https://journals.sagepub.com/doi/full/10.1177/0284185118798175
DOI
10.1177/0284185118798175
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
김동규(Kim, Dong Kyu) ORCID logo https://orcid.org/0000-0001-7322-2550
박성윤(Park, Sung Yoon)
원종윤(Won, Jong Yun)
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