Cited 6 times in
Real-world Data and Recommended Dosage of Non-vitamin K Oral Anticoagulants for Korean Patients
DC Field | Value | Language |
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dc.contributor.author | 정보영 | - |
dc.date.accessioned | 2018-11-08T16:40:33Z | - |
dc.date.available | 2018-11-08T16:40:33Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165114 | - |
dc.description.abstract | Regulatory approvals of non-vitamin K antagonist oral anticoagulants (NOACs) have been based on large randomized phase III trials evaluating dabigatran, rivaroxaban, apixaban, or edoxaban relative to warfarin for atrial fibrillation (AF). The results of the trials showed that all NOACs were at least non-inferior to warfarin in the prevention of stroke/thromboembolism and showed lower rates of intracranial bleeding than those associated with warfarin. However, the trials were designed differently, varied in the inclusion/exclusion criteria, and used either one dose or a low/high dose of the NOAC drug. Some of these differences have challenged the ability to directly compare various NOACs, and comparative data on effectiveness and intracranial bleeding are sparse in "real-world" patients. Real-world data complement data from large randomized phase III trials by providing new aspects of the "real-world" absolute risks of ischemic and hemorrhagic stroke associated with NOACs vs. warfarin. Moreover, "real-world" fragile patients might have been included (e.g., patients with increased risk of bleeding, liver disease, and chronic kidney disease), although these patients would be less represented in trials. This paper introduces recently published real-world data of NOACs and further suggests the recommended dosage of NOACs for Korean patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English, Korean | - |
dc.publisher | Korean Society of Circulation | - |
dc.relation.isPartOf | KOREAN CIRCULATION JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Real-world Data and Recommended Dosage of Non-vitamin K Oral Anticoagulants for Korean Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Boyoung Joung | - |
dc.identifier.doi | 10.4070/kcj.2017.0158 | - |
dc.contributor.localId | A03609 | - |
dc.relation.journalcode | J01952 | - |
dc.identifier.eissn | 1738-5555 | - |
dc.identifier.pmid | 29171208 | - |
dc.subject.keyword | Anticoagulants | - |
dc.subject.keyword | Atrial fibrillation | - |
dc.subject.keyword | Clinical trial | - |
dc.subject.keyword | Factor Xa inhibitors | - |
dc.contributor.alternativeName | Joung, Bo Young | - |
dc.contributor.affiliatedAuthor | 정보영 | - |
dc.citation.volume | 47 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 833 | - |
dc.citation.endPage | 841 | - |
dc.identifier.bibliographicCitation | KOREAN CIRCULATION JOURNAL, Vol.47(6) : 833-841, 2017 | - |
dc.identifier.rimsid | 60519 | - |
dc.type.rims | ART | - |
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