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Cited 4 times in

The Role of Autophagy in Systemic Metabolism and Human-Type Diabetes

DC FieldValueLanguage
dc.contributor.author이명식-
dc.date.accessioned2018-11-06T16:40:27Z-
dc.date.available2018-11-06T16:40:27Z-
dc.date.issued2018-
dc.identifier.issn1016-8478-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/165067-
dc.description.abstractAutophagy is critical for the maintenance of organelle function and intracellular nutrient environment. Autophagy is also involved in systemic metabolic homeostasis, and its dysregulation can lead to or accelerate the development of metabolic disorders. While the role of autophagy in the global metabolism of model organisms has been investigated mostly using site-specific genetic knockout technology, the impact of dysregulated autophagy on systemic metabolism has been unclear. Here, we review recent papers showing the role of autophagy in systemic metabolism and in the development of metabolic disorders. Also included are data suggesting the role of autophagy in human-type diabetes, which are different in several key aspects from murine models of diabetes. The results shown here support the view that autophagy modulation could be a new modality for the treatment of metabolic syndrome associated with lipid overload and human-type diabetes.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherKorean Society for Molecular and Cellular Biology-
dc.relation.isPartOfMolecules and Cells-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAutophagy/physiology*-
dc.subject.MESHDiabetes Mellitus/physiopathology*-
dc.subject.MESHEnergy Metabolism/physiology*-
dc.subject.MESHHomeostasis/physiology-
dc.subject.MESHHumans-
dc.subject.MESHInflammation/physiopathology-
dc.subject.MESHInsulin Resistance/physiology-
dc.subject.MESHMetabolic Diseases/physiopathology*-
dc.subject.MESHModels, Biological-
dc.subject.MESHObesity/physiopathology-
dc.titleThe Role of Autophagy in Systemic Metabolism and Human-Type Diabetes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentBioMedical Science Institute (의생명과학부)-
dc.contributor.googleauthorJinyoung Kim-
dc.contributor.googleauthorYu-Mi Lim-
dc.contributor.googleauthorMyung-Shik Lee-
dc.identifier.doi10.14348/molcells.2018.2228-
dc.contributor.localIdA02752-
dc.contributor.localIdA02752-
dc.relation.journalcodeJ02273-
dc.identifier.eissn0219-1032-
dc.identifier.pmid29370692-
dc.subject.keywordamyloid-
dc.subject.keywordautophagy-
dc.subject.keyworddiabetes-
dc.subject.keywordinflammasome-
dc.subject.keywordmetabolism-
dc.contributor.alternativeNameLee, Myung Shik-
dc.contributor.affiliatedAuthor이명식-
dc.citation.volume41-
dc.citation.number1-
dc.citation.startPage11-
dc.citation.endPage17-
dc.identifier.bibliographicCitationMolecules and Cells, Vol.41(1) : 11-17, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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