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The Role of Autophagy in Systemic Metabolism and Human-Type Diabetes

Authors
 Jinyoung Kim  ;  Yu-Mi Lim  ;  Myung-Shik Lee 
Citation
 Molecules and Cells, Vol.41(1) : 11-17, 2018 
Journal Title
 Molecules and Cells 
ISSN
 1016-8478 
Issue Date
2018
MeSH
Autophagy/physiology* ; Diabetes Mellitus/physiopathology* ; Energy Metabolism/physiology* ; Homeostasis/physiology ; Humans ; Inflammation/physiopathology ; Insulin Resistance/physiology ; Metabolic Diseases/physiopathology* ; Models, Biological ; Obesity/physiopathology
Keywords
amyloid ; autophagy ; diabetes ; inflammasome ; metabolism
Abstract
Autophagy is critical for the maintenance of organelle function and intracellular nutrient environment. Autophagy is also involved in systemic metabolic homeostasis, and its dysregulation can lead to or accelerate the development of metabolic disorders. While the role of autophagy in the global metabolism of model organisms has been investigated mostly using site-specific genetic knockout technology, the impact of dysregulated autophagy on systemic metabolism has been unclear. Here, we review recent papers showing the role of autophagy in systemic metabolism and in the development of metabolic disorders. Also included are data suggesting the role of autophagy in human-type diabetes, which are different in several key aspects from murine models of diabetes. The results shown here support the view that autophagy modulation could be a new modality for the treatment of metabolic syndrome associated with lipid overload and human-type diabetes.
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DOI
10.14348/molcells.2018.2228
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부)
Yonsei Authors
이명식(Lee, Myung Shik) ORCID logo https://orcid.org/0000-0003-3292-1720
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165067
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