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Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents

DC FieldValueLanguage
dc.contributor.author정금지-
dc.contributor.author지선하-
dc.date.accessioned2018-11-06T16:40:06Z-
dc.date.available2018-11-06T16:40:06Z-
dc.date.issued2016-
dc.identifier.issn0140-6736-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/165063-
dc.description.abstractBACKGROUND: Overweight and obesity are increasing worldwide. To help assess their relevance to mortality in different populations we conducted individual-participant data meta-analyses of prospective studies of body-mass index (BMI), limiting confounding and reverse causality by restricting analyses to never-smokers and excluding pre-existing disease and the first 5 years of follow-up. METHODS: Of 10 625 411 participants in Asia, Australia and New Zealand, Europe, and North America from 239 prospective studies (median follow-up 13·7 years, IQR 11·4-14·7), 3 951 455 people in 189 studies were never-smokers without chronic diseases at recruitment who survived 5 years, of whom 385 879 died. The primary analyses are of these deaths, and study, age, and sex adjusted hazard ratios (HRs), relative to BMI 22·5-<25·0 kg/m(2). FINDINGS: All-cause mortality was minimal at 20·0-25·0 kg/m(2) (HR 1·00, 95% CI 0·98-1·02 for BMI 20·0-<22·5 kg/m(2); 1·00, 0·99-1·01 for BMI 22·5-<25·0 kg/m(2)), and increased significantly both just below this range (1·13, 1·09-1·17 for BMI 18·5-<20·0 kg/m(2); 1·51, 1·43-1·59 for BMI 15·0-<18·5) and throughout the overweight range (1·07, 1·07-1·08 for BMI 25·0-<27·5 kg/m(2); 1·20, 1·18-1·22 for BMI 27·5-<30·0 kg/m(2)). The HR for obesity grade 1 (BMI 30·0-<35·0 kg/m(2)) was 1·45, 95% CI 1·41-1·48; the HR for obesity grade 2 (35·0-<40·0 kg/m(2)) was 1·94, 1·87-2·01; and the HR for obesity grade 3 (40·0-<60·0 kg/m(2)) was 2·76, 2·60-2·92. For BMI over 25·0 kg/m(2), mortality increased approximately log-linearly with BMI; the HR per 5 kg/m(2) units higher BMI was 1·39 (1·34-1·43) in Europe, 1·29 (1·26-1·32) in North America, 1·39 (1·34-1·44) in east Asia, and 1·31 (1·27-1·35) in Australia and New Zealand. This HR per 5 kg/m(2) units higher BMI (for BMI over 25 kg/m(2)) was greater in younger than older people (1·52, 95% CI 1·47-1·56, for BMI measured at 35-49 years vs 1·21, 1·17-1·25, for BMI measured at 70-89 years; pheterogeneity<0·0001), greater in men than women (1·51, 1·46-1·56, vs 1·30, 1·26-1·33; pheterogeneity<0·0001), but similar in studies with self-reported and measured BMI. INTERPRETATION: The associations of both overweight and obesity with higher all-cause mortality were broadly consistent in four continents. This finding supports strategies to combat the entire spectrum of excess adiposity in many populations. FUNDING: UK Medical Research Council, British Heart Foundation, National Institute for Health Research, US National Institutes of Health.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfLANCET-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAsia/epidemiology-
dc.subject.MESHAustralia/epidemiology-
dc.subject.MESHBody Mass Index*-
dc.subject.MESHCause of Death*-
dc.subject.MESHEurope/epidemiology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLinear Models-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMortality/trends*-
dc.subject.MESHNew Zealand/epidemiology-
dc.subject.MESHNorth America/epidemiology-
dc.subject.MESHOverweight/mortality-
dc.subject.MESHProspective Studies-
dc.titleBody-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents-
dc.typeArticle-
dc.contributor.collegeGraduate School of Public Health (보건대학원)-
dc.contributor.departmentGraduate School of Public Health (보건대학원)-
dc.contributor.googleauthorEmanuele Di Angelantonio-
dc.contributor.googleauthorShilpa N Bhupathiraju-
dc.contributor.googleauthorDavid Wormser-
dc.contributor.googleauthorPei Gao-
dc.contributor.googleauthorStephen Kaptoge-
dc.contributor.googleauthorAmy Berrington de Gonzalez-
dc.contributor.googleauthorBenjamin J Cairns-
dc.contributor.googleauthorRachel Huxley-
dc.contributor.googleauthorChandra L Jackson-
dc.contributor.googleauthorGrace Joshy-
dc.contributor.googleauthorSarah Lewington-
dc.contributor.googleauthorJoAnn E Manson-
dc.contributor.googleauthorNeil Murphy-
dc.contributor.googleauthorAlpa V Patel-
dc.contributor.googleauthorJonathan M Samet-
dc.contributor.googleauthorMark Woodward-
dc.contributor.googleauthorWei Zheng-
dc.contributor.googleauthorMaigen Zhou-
dc.contributor.googleauthorNarinder Bansal-
dc.contributor.googleauthorAurelio Barricarte-
dc.contributor.googleauthorBrian Carter-
dc.contributor.googleauthorJames R Cerhan-
dc.contributor.googleauthorRory Collins-
dc.contributor.googleauthorGeorge Davey Smith-
dc.contributor.googleauthorXianghua Fang-
dc.contributor.googleauthorOscar H Franco-
dc.contributor.googleauthorJane Green-
dc.contributor.googleauthorJim Halsey-
dc.contributor.googleauthorJanet S Hildebrand-
dc.contributor.googleauthorKeum Ji Jung-
dc.contributor.googleauthorRosemary J Korda-
dc.contributor.googleauthorDale F McLerran-
dc.contributor.googleauthorSteven C Moore-
dc.contributor.googleauthorLinda M O'Keeffe-
dc.contributor.googleauthorEllie Paige-
dc.contributor.googleauthorAnna Ramond-
dc.contributor.googleauthorGillian K Reeves-
dc.contributor.googleauthorBetsy Rolland-
dc.contributor.googleauthorCarlotta Sacerdote-
dc.contributor.googleauthorNaveed Sattar-
dc.contributor.googleauthorEleni Sofianopoulou-
dc.contributor.googleauthorJune Stevens-
dc.contributor.googleauthorMichael Thun-
dc.contributor.googleauthorHirotsugu Ueshima-
dc.contributor.googleauthorLing Yang-
dc.contributor.googleauthorYoung Duk Yun-
dc.contributor.googleauthorPeter Willeit-
dc.contributor.googleauthorEmily Banks-
dc.contributor.googleauthorValerie Beral-
dc.contributor.googleauthorZhengming Chen-
dc.contributor.googleauthorSusan M Gapstur-
dc.contributor.googleauthorMarc J Gunter-
dc.contributor.googleauthorPatricia Hartge-
dc.contributor.googleauthorSun Ha Jee-
dc.contributor.googleauthorTai-Hing Lam-
dc.contributor.googleauthorRichard Peto-
dc.contributor.googleauthorJohn D Potter-
dc.contributor.googleauthorWalter C Willett-
dc.contributor.googleauthorSimon G Thompson-
dc.contributor.googleauthorJohn Danesh-
dc.contributor.googleauthorFrank B Hu-
dc.identifier.doi10.1016/S0140-6736(16)30175-1-
dc.contributor.localIdA03580-
dc.contributor.localIdA03580-
dc.relation.journalcodeJ02152-
dc.identifier.eissn1474-547X-
dc.identifier.pmid27423262-
dc.contributor.alternativeNameJung, Keum Ji-
dc.contributor.affiliatedAuthor정금지-
dc.citation.volume10046-
dc.citation.startPage776-
dc.citation.endPage786-
dc.identifier.bibliographicCitationLANCET, Vol.10046 : 776-786, 2016-
dc.identifier.rimsid64806-
dc.type.rimsART-
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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