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Differential cytokine responses of murine macrophage J774A.1 cells to stainless steel coated with and without hydroxyapatite

Authors
 Mi Hee Lee  ;  Dong-Wook Han  ;  Hyun Sook Baek  ;  Hye Ryun Lim  ;  In-Seop Lee c, Kwon-Yong Lee d, Kyung Tae Kim e, Seung Jin Lee f, Jong-Chul Park 
Citation
 SURFACE & COATINGS TECHNOLOGY, Vol.201(9~11) : 5729-5732, 2007 
Journal Title
 SURFACE & COATINGS TECHNOLOGY 
ISSN
 0257-8972 
Issue Date
2007
Keywords
Cytokine ; Macrophage ; Biomaterials ; Stainless steel ; Hydroxyapatite
Abstract
Identification of cytokines secreted by macrophages and assessment of macrophage function in response to biomaterials is an important aspect of the host response to biomaterials. In the present study, differential cytokine responses of murine macrophage J774A.1 cells to stainless steel (SS) coated with and without hydroxyapatite (HA) were investigated. HA-coated SS was prepared through the deposition of thin (1 μm thick) calcium phosphate film by electron beam evaporation. SEM micrographs show that the surface of HA-coated SS was smoother than that of SS. Cell growth of J774A.1 macrophages onto HA-coated was about 1.5 times better than that onto intact SS. Reverse transcription-polymerase chain reaction analysis revealed that the mRNA of cytokines, such as tumor necrosis factor-α, transforming growth factor-β and granulocyte macrophage colony stimulating factor, was relatively less expressed in J774A.1 macrophages grown onto HA-coated SS. These results suggest that HA coatings may influence the expression of inflammatory cytokine in macrophages and improve the surface properties of metallic materials.
Full Text
https://www.sciencedirect.com/science/article/pii/S0257897206006293
DOI
10.1016/j.surfcoat.2006.07.064
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Lee, Mi Hee(이미희) ORCID logo https://orcid.org/0000-0002-9630-7044
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165021
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