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The Effect on Bone Outcomes of Home-based Exercise Intervention for Prostate Cancer Survivors Receiving Androgen Deprivation Therapy: A Pilot Randomized Controlled Trial

Authors
 Kim, Soo Hyun  ;  Seong, Do Hwan  ;  Yoon, Sang Min  ;  Choi, Young Deuk  ;  Choi, Eunju  ;  Song, Youngkyu  ;  Song, Hosook 
Citation
 Cancer Nursing, Vol.41(5) : 379-388, 2017 
Journal Title
 Cancer Nursing 
ISSN
 0162-220X 
Issue Date
2017
Abstract
BACKGROUND: Cancer treatment-induced bone loss has important long-term effects in prostate cancer survivors (PCSs) receiving androgen deprivation therapy (ADT), but little is known about preventive interventions. OBJECTIVE: The aim of this study was to examine the feasibility and preliminary effectiveness of a 6-month home-based exercise intervention in PCSs. METHODS: In this pilot, randomized controlled trial, 51 men (mean age, 70.8 years) were randomized to a 6-month home-based exercise intervention for preventing osteoporosis group (n = 26) or an exercise placebo intervention of stretching exercise group (n = 25). Primary outcomes were bone mineral density and bone turnover markers. Secondary outcomes were physical performance (level of physical activity, muscle strength, and balance) and health-related quality of life. RESULTS: The patient retention rate for 6 months was 80.4%. The mean adherence rate was 84.7% for weight-bearing exercise and 64.8% for resistance exercise. No adverse events during the study period were reported. Although primary outcomes did not differ significantly between the 2 groups, the home-based exercise intervention for preventing osteoporosis group demonstrated significantly greater increased muscle strength than the stretching exercise group. CONCLUSIONS: A home-based exercise program is relatively feasible and safe and may improve muscle strength but not bone outcomes. IMPLICATIONS FOR PRACTICE: Given the importance of preventing cancer treatment-induced bone loss among PCSs receiving ADT, a home-based exercise intervention can be considered, but further trials with a larger sample are required to determine its effect for bone outcomes.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00002820-201809000-00004&LSLINK=80&D=ovft
DOI
10.1097/NCC.0000000000000530
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
최영득(Choi, Young Deuk) ORCID logo https://orcid.org/0000-0002-8545-5797
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163798
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