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Effect of fenofibrate in 1113 patients at low-density lipoprotein cholesterol goal but high triglyceride levels: Real-world results and factors associated with triglyceride reduction

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dc.contributor.author강석민-
dc.contributor.author고영국-
dc.contributor.author김병극-
dc.contributor.author김중선-
dc.contributor.author박성하-
dc.contributor.author심지영-
dc.contributor.author이상학-
dc.contributor.author장양수-
dc.contributor.author장혁재-
dc.contributor.author최동훈-
dc.contributor.author하종원-
dc.contributor.author홍그루-
dc.contributor.author홍명기-
dc.date.accessioned2018-10-22T13:19:54Z-
dc.date.available2018-10-22T13:19:54Z-
dc.date.issued2018-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/163768-
dc.description.abstractFibrates are used in patients with dyslipidemia and high cardiovascular risk. However, information regarding drug response to fibrate has been highly limited. We investigated treatment results and factors associated with triglyceride reduction after fenofibrate therapy using large-scale real-world data. Patients with one or more cardiovascular risk factors, at low-density lipoprotein-cholesterol goal but with triglyceride level ≥150 mg/dL, and undergoing treatment with fenofibrate 135-160 mg for the first time were included in this retrospective observational study. The outcome variable was the percentage changes of TG levels. The achievement rate of triglyceride <150 mg/dL was additionally analyzed. Factors associated with treatment results were also analyzed. Among 2546 patients who were initially screened, 1113 patients were enrolled (median age: 61 years; male: 71%). After median follow-up of 4 months, the median change in triglyceride was -60%, and 49% of the patients reached triglyceride <150 mg/dL. After adjusting for confounding variables, female sex, non-diabetic status, coronary artery disease, lower baseline triglyceride, and no statin use were identified to be independently associated with achievement of triglyceride <150 mg/dL. Among them, female sex, non-diabetic status, and coronary artery disease were also related to median or greater percentage reduction of triglyceride. In conclusion, only half of the study patients reached triglyceride levels <150 mg/dL after real-world fenofibrate therapy. This study indicates that more attention is needed on some subgroups to obtain optimal triglyceride levels when treating with fenofibrate.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEffect of fenofibrate in 1113 patients at low-density lipoprotein cholesterol goal but high triglyceride levels: Real-world results and factors associated with triglyceride reduction-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorYeongmin Woo-
dc.contributor.googleauthorJeong-soo Shin-
dc.contributor.googleauthorChi-Young Shim-
dc.contributor.googleauthorJung-Sun Kim-
dc.contributor.googleauthorByeong-Keuk Kim-
dc.contributor.googleauthorSungha Park-
dc.contributor.googleauthorHyuk-Jae Chang-
dc.contributor.googleauthorGeu-Ru Hong-
dc.contributor.googleauthorYoung-Guk Ko-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorDonghoon Choi-
dc.contributor.googleauthorJong-Won Ha-
dc.contributor.googleauthorMyeong-Ki Hong-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorSang-Hak Lee-
dc.identifier.doi10.1371/journal.pone.0205006-
dc.contributor.localIdA00037-
dc.contributor.localIdA00127-
dc.contributor.localIdA00493-
dc.contributor.localIdA00961-
dc.contributor.localIdA01512-
dc.contributor.localIdA02213-
dc.contributor.localIdA02833-
dc.contributor.localIdA03448-
dc.contributor.localIdA03490-
dc.contributor.localIdA04053-
dc.contributor.localIdA04257-
dc.contributor.localIdA04386-
dc.contributor.localIdA04391-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid30286170-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.alternativeNameKo, Young Guk-
dc.contributor.alternativeNameKim, Byeong Keuk-
dc.contributor.alternativeNameKim, Jung Sun-
dc.contributor.alternativeNamePark, Sung Ha-
dc.contributor.alternativeNameShim, Chi Young-
dc.contributor.alternativeNameLee, Snag Hak-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameChang, Hyuck Jae-
dc.contributor.alternativeNameChoi, Dong Hoon-
dc.contributor.alternativeNameHa, Jong Won-
dc.contributor.alternativeNameHong, Geu Ru-
dc.contributor.alternativeNameHong, Myeong Ki-
dc.contributor.affiliatedAuthorKang, Seok Min-
dc.contributor.affiliatedAuthorKo, Young Guk-
dc.contributor.affiliatedAuthorKim, Byeong Keuk-
dc.contributor.affiliatedAuthorKim, Jung Sun-
dc.contributor.affiliatedAuthorPark, Sung Ha-
dc.contributor.affiliatedAuthorShim, Chi Young-
dc.contributor.affiliatedAuthorLee, Snag Hak-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorChang, Hyuck Jae-
dc.contributor.affiliatedAuthorChoi, Dong Hoon-
dc.contributor.affiliatedAuthorHa, Jong Won-
dc.contributor.affiliatedAuthorHong, Geu Ru-
dc.contributor.affiliatedAuthorHong, Myeong Ki-
dc.citation.volume13-
dc.citation.number10-
dc.citation.startPagee0205006-
dc.identifier.bibliographicCitationPLOS ONE, Vol.13(10) : e0205006, 2018-
dc.identifier.rimsid59063-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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