Cited 23 times in
Impact of host-pathogen-treatment tripartite components on early mortality of patients with Escherichia coli bloodstream infection: Prospective observational study
DC Field | Value | Language |
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dc.contributor.author | 김도균 | - |
dc.contributor.author | 이혁민 | - |
dc.contributor.author | 정석훈 | - |
dc.date.accessioned | 2018-10-22T13:18:18Z | - |
dc.date.available | 2018-10-22T13:18:18Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/163733 | - |
dc.description.abstract | BACKGROUND: Risk factors affecting early morality of patients with Escherichia coli bloodstream infection (BSI) were investigated including the host-pathogen-treatment tripartite components. METHODS: Six general hospitals in South Korea participated in this multicentre prospective observational study from May 2016 to April 2017 and a total of 1492 laboratory-confirmed E. coli BSI cases were studied. Cox regression was used to estimate risks of the primary endpoint, i.e., all-cause mortality within 30 days from the initial blood culture. Six multivariate analysis models were constructed in accordance to the clinical importance and intra- and inter-component multicollinearity. FINDINGS: Among the 1492 E. coli BSI cases, 9.5% (n = 141) patients expired within 30 days. Six models of multivariate analysis indicated risk factors of critical illness, primary infection of peritoneum, and chronic liver disease including cirrhosis for host variables; of phylogenetic group B2, ST131-sublineage H30Rx, multidrug resistance, group 1 CTX-M extended-spectrum beta-lactamase production, and having either of fyuA, afa, and sfa/foc virulence genes for causative E. coli pathogen variables; and of delayed definitive therapy for antimicrobial treatment variables. In addition, as a protective factor, primary urinary tract infection was identified. INTERPRETATION: Despite decades' effort searching for the risk factors for E. coli BSI, systemic understanding covering the entire tripartite component is still lacking. This study detailed the organic impact of host-pathogen-treatment tripartite components for early mortality in patients with E. coli BSI. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | EBIOMEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Impact of host-pathogen-treatment tripartite components on early mortality of patients with Escherichia coli bloodstream infection: Prospective observational study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Laboratory Medicine | - |
dc.contributor.googleauthor | Eun-Jeong Yoon | - |
dc.contributor.googleauthor | Min Hyuk Choi | - |
dc.contributor.googleauthor | Yoon Soo Park | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Dokyun Kim | - |
dc.contributor.googleauthor | Hyukmin Lee | - |
dc.contributor.googleauthor | Kyeong Seob Shin | - |
dc.contributor.googleauthor | Jong Hee Shine | - |
dc.contributor.googleauthor | Young Uh | - |
dc.contributor.googleauthor | Young Ah Kim | - |
dc.contributor.googleauthor | Jeong Hwan Shing | - |
dc.contributor.googleauthor | SeokHoon Jeong | - |
dc.identifier.doi | 10.1016/j.ebiom.2018.08.029 | - |
dc.contributor.localId | A04891 | - |
dc.contributor.localId | A03286 | - |
dc.contributor.localId | A03619 | - |
dc.relation.journalcode | J03279 | - |
dc.identifier.eissn | 2352-3964 | - |
dc.identifier.pmid | 30139627 | - |
dc.subject.keyword | Bloodstream infection | - |
dc.subject.keyword | CTX-M ESBL | - |
dc.subject.keyword | Delayed definitive treatment | - |
dc.subject.keyword | Early mortality | - |
dc.subject.keyword | Escherichia coli | - |
dc.subject.keyword | ST131 | - |
dc.contributor.alternativeName | Kim, Dokyun | - |
dc.contributor.alternativeName | Lee, Hyuk Min | - |
dc.contributor.alternativeName | Jeong, Seok Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Dokyun | - |
dc.contributor.affiliatedAuthor | Lee, Hyuk Min | - |
dc.contributor.affiliatedAuthor | Jeong, Seok Hoon | - |
dc.citation.volume | 35 | - |
dc.citation.startPage | 76 | - |
dc.citation.endPage | 86 | - |
dc.identifier.bibliographicCitation | EBIOMEDICINE, Vol.35 : 76-86, 2018 | - |
dc.identifier.rimsid | 59030 | - |
dc.type.rims | ART | - |
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