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Effect of the midazolam added with propofol‐based sedation in esophagogastroduodenoscopy: A randomized trial

DC FieldValueLanguage
dc.contributor.author김은혜-
dc.contributor.author박준철-
dc.contributor.author신성관-
dc.contributor.author이상길-
dc.contributor.author이용찬-
dc.date.accessioned2018-10-22T13:17:08Z-
dc.date.available2018-10-22T13:17:08Z-
dc.date.issued2018-
dc.identifier.issn0815-9319-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/163705-
dc.description.abstractBACKGROUND AND AIM: Although propofol has been widely used for sedation during esophagogastroduodenoscopy (EGD), adverse events including hypoxia and hypotension may be a concern in the propofol-based sedation. We aimed to analyze whether administration of midazolam would improve safety and efficacy of propofol-based sedation in EGD. METHODS: One hundred twenty patients who were scheduled to undergo diagnostic EGD were randomly assigned to either midazolam plus propofol (MP) or propofol alone groups. In the MP group, 2 mg of midazolam and 10 mg of propofol were given initially. In the propofol alone group, 40-60 mg of propofol was given initially. In both groups, 20 mg of propofol was given repeatedly to maintain moderate sedation as needed. Vital signs including oxygen saturation were monitored every 2 min. After the patients fully recovered, satisfaction score was investigated from endoscopists, nurses, and patients, respectively. RESULTS: The baseline characteristics did not differ between the MP and propofol alone groups. The mean required doses of propofol was (mean ± standard deviation) 0.3 ± 0.3 and 0.8 ± 0.2 mg/kg in the MP and propofol alone groups, respectively (P < 0.001). In addition, sedation-related adverse events and recovery time did not differ between the two groups. The proportion of satisfactory did not differ between the two groups (MP vs propofol alone; proportion; patient, 95.0% vs 93.3%, P > 0.999; endoscopist, 73.3% vs 80.0%, P = 0.064; nurse, 73.3% vs 76.7%, P = 0.551). CONCLUSION: Adding midazolam to propofol did not reduced the safety and efficacy, and sedation using propofol alone could be suitable for sedation during diagnostic EGD-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherBlackwell Scientific Publications-
dc.relation.isPartOfJournal of Gastroenterology and Hepatology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHConscious Sedation/adverse effects-
dc.subject.MESHConscious Sedation/methods*-
dc.subject.MESHConscious Sedation/psychology-
dc.subject.MESHDrug Combinations-
dc.subject.MESHEndoscopy, Digestive System*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMidazolam/administration & dosage*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPersonal Satisfaction-
dc.subject.MESHPropofol/administration & dosage*-
dc.subject.MESHProspective Studies-
dc.subject.MESHSafety-
dc.titleEffect of the midazolam added with propofol‐based sedation in esophagogastroduodenoscopy: A randomized trial-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorEun Hye Kim-
dc.contributor.googleauthorJun Chul Park-
dc.contributor.googleauthorSung Kwan Shin-
dc.contributor.googleauthorYong Chan Lee-
dc.contributor.googleauthorSang Kil Lee-
dc.identifier.doi10.1111/jgh.14026-
dc.contributor.localIdA00827-
dc.contributor.localIdA01676-
dc.contributor.localIdA02112-
dc.contributor.localIdA02812-
dc.contributor.localIdA02988-
dc.relation.journalcodeJ01417-
dc.identifier.eissn1440-1746-
dc.identifier.pmid29048708-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1111/jgh.14026-
dc.subject.keywordendoscopy-
dc.subject.keywordmidazolam-
dc.subject.keywordpropofol-
dc.subject.keywordsedation-
dc.contributor.alternativeNameKim, Eun Hye-
dc.contributor.alternativeNamePark, Jun Chul-
dc.contributor.alternativeNameShin, Sung Kwan-
dc.contributor.alternativeNameLee, Sang Kil-
dc.contributor.alternativeNameLee, Yong Chan-
dc.contributor.affiliatedAuthorKim, Eun Hye-
dc.contributor.affiliatedAuthorPark, Jun Chul-
dc.contributor.affiliatedAuthorShin, Sung Kwan-
dc.contributor.affiliatedAuthorLee, Sang Kil-
dc.contributor.affiliatedAuthorLee, Yong Chan-
dc.citation.volume33-
dc.citation.number4-
dc.citation.startPage894-
dc.citation.endPage899-
dc.identifier.bibliographicCitationJournal of Gastroenterology and Hepatology, Vol.33(4) : 894-899, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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