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Prospective Single Arm Study on the Effect of Ilaprazole in Patients with Heartburn but No Reflux Esophagitis

DC FieldValueLanguage
dc.contributor.author김현기-
dc.contributor.author이상길-
dc.date.accessioned2018-10-22T13:17:06Z-
dc.date.available2018-10-22T13:17:06Z-
dc.date.issued2018-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/163704-
dc.description.abstractPURPOSE: Patients with gastroesophageal reflux disease without esophagitis show varying responses to proton pump inhibitors (PPIs). The aim of this study was to objectively evaluate the effect of a new PPI, ilaprazole, on patients with heartburn but without reflux esophagitis. MATERIALS AND METHODS: This prospective study was performed on 20 patients with heartburn but without reflux esophagitis. All patients underwent upper endoscopy and 24-hr combined multichannel intraluminal impedance and pH esophageal monitoring (MII-pH). They were then treated with ilaprazole (20 mg) once daily for 4 weeks. The GerdQ questionnaire, histologic findings, and inflammatory biomarkers were used for assessment before and after ilaprazole. RESULTS: Among the 20 patients, 13 (65%) showed GerdQ score ≥8. Based on MII-pH results, patients were classified as true nonerosive reflux disease (n=2), hypersensitive esophagus (n=10), and functional heartburn (n=8). After treatment, patients showed a statistically significant improvement in GerdQ score (p<0.001). Among histopathologic findings, basal cell hyperplasia, papillary elongation, and infiltration of intraepithelial T lymphocytes improved significantly (p=0.008, p=0.021, and p=0.008; respectively). Expression of TNF-α, IL-8, TRPV1, and MCP-1 decreased marginally after treatment (p=0.049, p=0.046, p=0.045, and p=0.042; respectively). CONCLUSION: Daily ilaprazole (20 mg) is efficacious in improving symptom scores, histopathologic findings, and inflammatory biomarkers in patients with heartburn but no reflux esophagitis.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleProspective Single Arm Study on the Effect of Ilaprazole in Patients with Heartburn but No Reflux Esophagitis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pathology-
dc.contributor.googleauthorIn Ji Song-
dc.contributor.googleauthorHyun Ki Kim-
dc.contributor.googleauthorNa Keum Lee-
dc.contributor.googleauthorSang Kil Lee-
dc.identifier.doi10.3349/ymj.2018.59.8.951-
dc.contributor.localIdA01108-
dc.contributor.localIdA02812-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid30187702-
dc.subject.keywordHeartburn-
dc.subject.keywordilaprazole-
dc.subject.keywordproton pump inhibitors-
dc.subject.keywordreflux esophagitis-
dc.contributor.alternativeNameKim, Hyun Ki-
dc.contributor.alternativeNameLee, Sang Kil-
dc.contributor.affiliatedAuthorKim, Hyun Ki-
dc.contributor.affiliatedAuthorLee, Sang Kil-
dc.citation.volume59-
dc.citation.number8-
dc.citation.startPage951-
dc.citation.endPage959-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.59(8) : 951-959, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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