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Severe hypoglycemia is a risk factor for atrial fibrillation in type 2 diabetes mellitus: Nationwide population-based cohort study

Authors
 Seung-Hyun Ko  ;  Yong-Moon Park  ;  Jae-Seung Yun  ;  Seon-Ah Cha  ;  Eue-Keun Choi  ;  Kyungdo Han  ;  Eugene Han  ;  Yong-ho Lee  ;  Yu-Bae Ahn 
Citation
 Journal of Diabetes and Its Complications, Vol.32(2) : 157-163, 2018 
Journal Title
 Journal of Diabetes and Its Complications 
ISSN
 1056-8727 
Issue Date
2018
Keywords
All-cause mortality ; Atrial fibrillation ; Cardiac arrhythmia ; Diabetes type 2 ; Severe hypoglycemia
Abstract
AIMS: This study investigated the association between severe hypoglycemia (SH) and new onset atrial fibrillation (AF) and all-cause mortality in adult patients with type 2 diabetes mellitus (T2DM). METHODS: Retrospective data on patients with T2DM aged between 30 and 75years who received healthcare checkups from January 1, 2005 to December 31, 2008 were analyzed using the National Health Insurance Database in Korea. The primary outcome was newly diagnosed non-valvular AF occurring after SH episode using ICD-10 codes. RESULTS: Among 1,509,280 subjects, 10,864 (0.72%) patients had experienced SH events in the three years prior to health examination, and a total of 48,916 (3.24%) first-time AF episodes occurred during the follow-up period of 8.5years. The incidence of AF was significantly higher in the group with SH than the group without SH. After multivariable adjustment, previous SH was a significant risk factor for the development of AF (HR 1.10, 95% CI 1.01-1.19). All-cause mortality was also significantly increased in patients with previous SH events and prior SH with subsequent AF occurrence, compared to patients without SH events. CONCLUSIONS: Prior SH events were associated with a higher risk of new onset AF and all-cause mortality in patients with T2DM.
Full Text
https://www.sciencedirect.com/science/article/pii/S1056872717307171
DOI
10.1016/j.jdiacomp.2017.09.009
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
이용호(Lee, Yong Ho) ORCID logo https://orcid.org/0000-0002-6219-4942
한유진(Han, Eu Gene)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163697
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