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Fasting Glucose and All-Cause Mortality by Age in Diabetes: A Prospective Cohort Study

Authors
 Sang-Wook Yi  ;  Sangkyu Park  ;  Yong-ho Lee  ;  Beverley Balkau  ;  Jee-Jeon Yi 
Citation
 Diabetes Care, Vol.41(3) : 623-626, 2018 
Journal Title
 Diabetes Care 
ISSN
 0149-5992 
Issue Date
2018
MeSH
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Blood Glucose/metabolism* ; Diabetes Mellitus/blood* ; Fasting* ; Female ; Follow-Up Studies ; Humans ; Hypoglycemia/blood* ; Male ; Middle Aged ; Mortality* ; Prevalence ; Proportional Hazards Models ; Prospective Studies ; Young Adult
Abstract
OBJECTIVE: To examine associations between fasting glucose and mortality and to identify the levels associated with lowest mortality by age in diabetes. RESEARCH DESIGN AND METHODS: A total of 359,645 Korean adults with known prevalent diabetes participated in health screening during 2001-2004 and were followed up until 2013. RESULTS: U-curve associations were found. Fasting glucose levels associated with the lowest mortality were ∼90-130 mg/dL, except for in those aged 18-44 years (∼80-95 mg/dL). Multivariable-adjusted hazard ratios of fasting glucose <65, 65-74, 75-84, 140-169, 170-199, and ≥200 mg/dL were 1.46, 1.12, 1.09, 1.12, 1.31, and 1.78, respectively, compared with 85-99 mg/dL. CONCLUSIONS: Optimal fasting glucose range for survival is higher in adults with than without known prevalent diabetes, except, perhaps, younger adults. Tight glucose control may lessen premature death in younger adults with diabetes. Hypoglycemia (<65 mg/dL) was associated with higher mortality than was fasting glucose 170-199 mg/dL, while fasting glucose 65-84 mg/dL had risks comparable with those at levels 140-169 mg/dL in diabetes.
Full Text
http://care.diabetesjournals.org/content/41/3/623.long
DOI
10.2337/dc17-1872
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
이용호(Lee, Yong Ho) ORCID logo https://orcid.org/0000-0002-6219-4942
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163694
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