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Anti-resorptive effect of pamidronate on extraction socket wall in dogs

Authors
 Jae‐Kook Cha  ;  Yoo‐Kyung Sun  ;  Myong Ji Kim  ;  Mariano Sanz  ;  Ui‐Won Jung 
Citation
 Clinical Oral Implants Research, Vol.29(7) : 688-696, 2018 
Journal Title
 Clinical Oral Implants Research 
ISSN
 0905-7161 
Issue Date
2018
Keywords
animal experiment ; bisphosphonate ; extraction ; histology ; ridge preservation
Abstract
AIM: The aim of this experimental in vivo investigation was to assess the anti-resorptive effect of low concentration pamidronate on the buccal plate in fresh extraction sockets. MATERIALS AND METHODS: The distal roots of the third premolars were extracted bilaterally in six dogs. A collagen matrix loaded with either pamidronate (test group) or saline (control group) was positioned on the outer surface of buccal bone immediately after tooth extraction and subsequently covered with a coronally advanced flap. Histological and histomorphometric outcomes were evaluated 12 weeks later. RESULTS: The mean vertical distance between the buccal and lingual bone crest differed significantly between the test and control groups (0.52 ± 0.43 and 2.21 ± 1.15 mm, respectively; p = .037). The width of the buccal bone 1 mm below the crest was significantly wider in the test group than the control group (4.68 ± 0.68 vs. 3.44 ± 0.60 mm, p < .001). CONCLUSIONS: Local application of pamidronate onto a collagen matrix may reduce the dimensional changes of the buccal bone plate both vertically and horizontally.
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1111/clr.13260
DOI
10.1111/clr.13260
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Sun, Yoo Kyung(선유경)
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Cha, Jae Kook(차재국) ORCID logo https://orcid.org/0000-0001-6817-9834
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163682
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