Anti-resorptive effect of pamidronate on extraction socket wall in dogs

Abstract

AimThe aim of this experimental in vivo investigation was to assess the anti-resorptive effect of low concentration pamidronate on the buccal plate in fresh extraction sockets. Materials and methodsThe distal roots of the third premolars were extracted bilaterally in six dogs. A collagen matrix loaded with either pamidronate (test group) or saline (control group) was positioned on the outer surface of buccal bone immediately after tooth extraction and subsequently covered with a coronally advanced flap. Histological and histomorphometric outcomes were evaluated 12weeks later. ResultsThe mean vertical distance between the buccal and lingual bone crest differed significantly between the test and control groups (0.520.43 and 2.21 +/- 1.15mm, respectively; p=.037). The width of the buccal bone 1mm below the crest was significantly wider in the test group than the control group (4.68 +/- 0.68 vs. 3.44 +/- 0.60mm, p<.001). ConclusionsLocal application of pamidronate onto a collagen matrix may reduce the dimensional changes of the buccal bone plate both vertically and horizontally.