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Significant predictors of medically diagnosed chronic obstructive pulmonary disease in patients with preserved ratio impaired spirometry: a 3-year cohort study.

DC FieldValueLanguage
dc.contributor.author김형중-
dc.contributor.author박혜정-
dc.contributor.author변민광-
dc.date.accessioned2018-10-11T09:00:00Z-
dc.date.available2018-10-11T09:00:00Z-
dc.date.issued2018-
dc.identifier.issn1465-9921-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/163549-
dc.description.abstractBACKGROUND: Preserved ratio impaired spirometry (PRISm) is an incompletely understood respiratory condition. We investigated the incidence and significant predictive factors of chronic obstructive pulmonary disease (COPD) in PRISm patients. METHODS: From 11,922 subjects registered in the Korea National Health and Nutrition Examination Survey, never or light smokers, young subjects, and those already medically diagnosed with COPD (defined by ICD-10 code and prescribed medication) were excluded. The 2666 remaining subjects were categorized into PRISm (normal forced expiratory volume in the first second [FEV1]/force vital capacity [FVC] [≥ 0.7] and low FEV1 (< 80%); n = 313); normal (n = 1666); and unrevealed COPD groups (FEV1/FVC ratio <  0.7; n = 687). These groups were compared using matched Health Insurance Review and Assessment Service data over a 3-year follow-up. RESULTS: COPD incidence in PRISm patients (17/1000 person-year [PY]) was higher than that in normal subjects (4.3/1000 PY; P <  0.001), but lower than that in unrevealed COPD patients (45/1000 PY; P < 0.001). PRISm patients visited hospitals, took COPD medication, and incurred hospitalization costs more frequently than normal subjects, but less frequently than unrevealed COPD patients. In the overall sample, age, FVC, FEV1, dyspnea, and wheezing were significant predictors of COPD, but in PRISm patients, only age (OR, 1.14; P = 0.002) and wheezing (OR, 4.56; P = 0.04) were significant predictors. CONCLUSION: PRISm patients are likely to develop COPD, and should be monitored carefully, especially older patients and those with wheezing, regardless of lung function.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherBioMed Central Ltd-
dc.relation.isPartOfRESPIRATORY RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleSignificant predictors of medically diagnosed chronic obstructive pulmonary disease in patients with preserved ratio impaired spirometry: a 3-year cohort study.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorHye Jung Park-
dc.contributor.googleauthorMin Kwang Byun-
dc.contributor.googleauthorChin Kook Rhee-
dc.contributor.googleauthorKyungjoo Kim-
dc.contributor.googleauthorHyung Jung Kim-
dc.contributor.googleauthorKwang-Ha Yoo-
dc.identifier.doi10.1186/s12931-018-0896-7-
dc.contributor.localIdA01158-
dc.contributor.localIdA01769-
dc.contributor.localIdA01848-
dc.relation.journalcodeJ02616-
dc.identifier.eissn1465-993X-
dc.identifier.pmid30249256-
dc.subject.keywordChronic obstructive pulmonary disorder-
dc.subject.keywordPrognosis-
dc.subject.keywordSpirometry-
dc.contributor.alternativeNameKim, Hyung Jung-
dc.contributor.alternativeNamePark, Hye Jung-
dc.contributor.alternativeNameByun, Min Kwang-
dc.contributor.affiliatedAuthorKim, Hyung Jung-
dc.contributor.affiliatedAuthorPark, Hye Jung-
dc.contributor.affiliatedAuthorByun, Min Kwang-
dc.citation.volume19-
dc.citation.number1-
dc.citation.startPage185-
dc.identifier.bibliographicCitationRESPIRATORY RESEARCH, Vol.19(1) : 185, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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