Cited 11 times in
Protein Kinase A phosphorylates NCoR to enhance its nuclear translocation and repressive function in human prostate cancer cells
DC Field | Value | Language |
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dc.contributor.author | 유정윤 | - |
dc.contributor.author | 최효경 | - |
dc.contributor.author | 박수연 | - |
dc.contributor.author | 윤호근 | - |
dc.date.accessioned | 2018-10-10T08:12:00Z | - |
dc.date.available | 2018-10-10T08:12:00Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0021-9541 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/163383 | - |
dc.description.abstract | Protein kinase A (PKA) phosphorylates diverse protein substrates to modulate their function. In this study, we found that PKA specifically phosphorylates the RD1 (repression domain 1) domain of nuclear receptor corepressor (NCoR). We demonstrated that the Serine-70 of NCoR is identified the critical amino acid for PKA-dependent NCoR phosphorylation. Importantly, we found that PKA-dependent phosphorylation enhances the nuclear translocation of NCoR. More importantly, the activation of PKA enhanced the repressive activity of NCoR in a reporter assay and potentiated the antagonist activity in the androgen receptor (AR)-mediated transcription. Taken together, these results uncover a regulatory mechanism by which PKA positively modulates NCoR function in transcriptional regulation in prostate cancer. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Liss | - |
dc.relation.isPartOf | JOURNAL OF CELLULAR PHYSIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Active Transport, Cell Nucleus | - |
dc.subject.MESH | Cyclic AMP-Dependent Protein Kinases/metabolism* | - |
dc.subject.MESH | Enzyme Activation | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic | - |
dc.subject.MESH | HeLa Cells | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kallikreins/genetics | - |
dc.subject.MESH | Kallikreins/metabolism | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mutation | - |
dc.subject.MESH | Nuclear Receptor Co-Repressor 1/genetics | - |
dc.subject.MESH | Nuclear Receptor Co-Repressor 1/metabolism* | - |
dc.subject.MESH | Phosphorylation | - |
dc.subject.MESH | Promoter Regions, Genetic | - |
dc.subject.MESH | Prostate-Specific Antigen/genetics | - |
dc.subject.MESH | Prostate-Specific Antigen/metabolism | - |
dc.subject.MESH | Prostatic Neoplasms/enzymology* | - |
dc.subject.MESH | Prostatic Neoplasms/genetics | - |
dc.subject.MESH | Protein Binding | - |
dc.subject.MESH | Protein Structure, Tertiary | - |
dc.subject.MESH | RNA Interference | - |
dc.subject.MESH | Receptors, Androgen/genetics | - |
dc.subject.MESH | Receptors, Androgen/metabolism | - |
dc.subject.MESH | Serine | - |
dc.subject.MESH | Signal Transduction | - |
dc.subject.MESH | Transcription, Genetic | - |
dc.subject.MESH | Transfection | - |
dc.title | Protein Kinase A phosphorylates NCoR to enhance its nuclear translocation and repressive function in human prostate cancer cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Biochemistry & Molecular Biology | - |
dc.contributor.googleauthor | Hyo‐Kyoung Choi | - |
dc.contributor.googleauthor | Jung‐Yoon Yoo | - |
dc.contributor.googleauthor | Mi‐Hyeon Jeong | - |
dc.contributor.googleauthor | Soo‐Yeon Park | - |
dc.contributor.googleauthor | Dong‐Myoung Shin | - |
dc.contributor.googleauthor | Sung‐Wuk Jang | - |
dc.contributor.googleauthor | Ho‐Geun Yoon | - |
dc.contributor.googleauthor | Kyung‐Chul Choi | - |
dc.identifier.doi | 10.1002/jcp.24269 | - |
dc.contributor.localId | A02502 | - |
dc.contributor.localId | A04225 | - |
dc.contributor.localId | A01534 | - |
dc.contributor.localId | A02625 | - |
dc.relation.journalcode | J01304 | - |
dc.identifier.eissn | 1097-4652 | - |
dc.identifier.pmid | 23129261 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.24269 | - |
dc.contributor.alternativeName | Yoo, Jung Yoon | - |
dc.contributor.alternativeName | Choi, Hyo Kyoung | - |
dc.contributor.alternativeName | Park, Soo Yeon | - |
dc.contributor.alternativeName | Yoon, Ho Geun | - |
dc.contributor.affiliatedAuthor | Yoo, Jung Yoon | - |
dc.contributor.affiliatedAuthor | Choi, Hyo Kyoung | - |
dc.contributor.affiliatedAuthor | Park, Soo Yeon | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Geun | - |
dc.contributor.affiliatedAuthor | 유정윤 | - |
dc.citation.volume | 228 | - |
dc.citation.startPage | 1159 | - |
dc.citation.endPage | 1165 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELLULAR PHYSIOLOGY, Vol.228 : 1159-1165, 2013 | - |
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