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Early prediction of long-term response to cabergoline in patients with macroprolactinomas

DC FieldValueLanguage
dc.contributor.author구철룡-
dc.contributor.author이영기-
dc.contributor.author김의현-
dc.contributor.author이은직-
dc.contributor.author김선호-
dc.date.accessioned2018-10-02T16:40:06Z-
dc.date.available2018-10-02T16:40:06Z-
dc.date.issued2014-
dc.identifier.issn2093-596X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/163343-
dc.description.abstractBACKGROUND: Cabergoline is typically effective for treating prolactinomas; however, some patients display cabergoline resistance, and the early characteristics of these patients remain unclear. We analyzed early indicators predicting long-term response to cabergoline. METHODS: We retrospectively reviewed the cases of 44 patients with macroprolactinomas who received cabergoline as first-line treatment; the patients were followed for a median of 16 months. The influence of various clinical parameters on outcomes was evaluated. RESULTS: Forty patients (90.9%) were treated medically and displayed tumor volume reduction (TVR) of 74.7%, a prolactin normalization (NP) rate of 81.8%, and a complete response (CR; TVR >50% with NP, without surgery) rate of 70.5%. Most patients (93.1%) with TVR ≥25% and NP at 3 months eventually achieved CR, whereas only 50% of patients with TVR ≥25% without NP and no patients with TVR <25% achieved CR. TVR at 3 months was strongly correlated with final TVR (R=0.785). Patients with large macroadenomas exhibited a low NP rate at 3 months, but eventually achieved TVR and NP rates similar to those of patients with smaller tumors. Surgery independently reduced the final dose of cabergoline (β=-1.181 mg/week), and two of four patients who underwent surgery were able to discontinue cabergoline. CONCLUSION: Determining cabergoline response using TVR and NP 3 months after treatment is useful for predicting later outcomes. However, further cabergoline administration should be considered for patients with TVR >25% at 3 months without NP, particularly those with huge prolactinomas, because a delayed response may be achieved. As surgery can reduce the cabergoline dose necessary for successful disease control, it should be considered for cabergoline-resistant patients.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherKorean Endocrine Society-
dc.relation.isPartOfEndocrinology and Metabolism (대한내분비학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEarly prediction of long-term response to cabergoline in patients with macroprolactinomas-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorYoungki Lee-
dc.contributor.googleauthorCheol Ryong Ku-
dc.contributor.googleauthorEui-Hyun Kim-
dc.contributor.googleauthorJae Won Hong-
dc.contributor.googleauthorEun Jig Lee-
dc.contributor.googleauthorSun Ho Kim-
dc.identifier.doi10.3803/EnM.2014.29.3.280-
dc.contributor.localIdA00201-
dc.contributor.localIdA02953-
dc.contributor.localIdA00837-
dc.contributor.localIdA03050-
dc.contributor.localIdA00560-
dc.relation.journalcodeJ00773-
dc.identifier.eissn2093-5978-
dc.identifier.pmid25309786-
dc.subject.keywordCabergoline-
dc.subject.keywordDopamine-
dc.subject.keywordHyperprolactinemia-
dc.subject.keywordProlactinoma-
dc.contributor.alternativeNameKu, Cheol Ryong-
dc.contributor.alternativeNameLee, Young Ki-
dc.contributor.alternativeNameKim, Eui Hyun-
dc.contributor.alternativeNameLee, Eun Jig-
dc.contributor.alternativeNameKim, Sun Ho-
dc.contributor.affiliatedAuthorKu, Cheol Ryong-
dc.contributor.affiliatedAuthorLee, Young Ki-
dc.contributor.affiliatedAuthorKim, Eui Hyun-
dc.contributor.affiliatedAuthorLee, Eun Jig-
dc.contributor.affiliatedAuthorKim, Sun Ho-
dc.citation.volume29-
dc.citation.startPage280-
dc.citation.endPage292-
dc.identifier.bibliographicCitationEndocrinology and Metabolism (대한내분비학회지), Vol.29 : 280-292, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

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