Cited 2 times in
Postoperative adjuvant chemotherapy is associated with a lower incidence of colorectal adenomas in patients with previous colorectal cancer.
DC Field | Value | Language |
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dc.contributor.author | 김성배 | - |
dc.contributor.author | 김원호 | - |
dc.contributor.author | 김태일 | - |
dc.contributor.author | 박수정 | - |
dc.contributor.author | 이희승 | - |
dc.contributor.author | 천재희 | - |
dc.contributor.author | 홍성필 | - |
dc.date.accessioned | 2018-09-28T08:58:43Z | - |
dc.date.available | 2018-09-28T08:58:43Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0016-5107 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/163296 | - |
dc.description.abstract | BACKGROUND AND AIMS: The effects of chemotherapeutic agents on the development of colorectal adenomas in patients with previous colorectal cancer (CRC) are not defined. Therefore, we evaluated the potential effect of adjuvant chemotherapy on the incidence of colorectal adenomas in patients with previous CRC. METHODS: We selected patients with low-risk stage II CRC with or without postoperative 5-fluorouracil-based adjuvant chemotherapy to reduce selection bias. Among 1808 patients with stage II CRC who underwent colonoscopic surveillance after curative resection of CRC between 2006 and 2013, 192 patients were retrospectively enrolled in this study after matching for age and sex. The patients were divided into 96 patients receiving and 96 patients not receiving 5-fluorouracil-based chemotherapy. RESULTS: Forty patients (41.7%) exhibited colorectal adenomas among 96 patients who received adjuvant chemotherapy, compared with 50 patients (52.1%) with colorectal adenomas among 96 patients who received surgery only. The incidence rate of advanced adenoma was significantly lower in the chemotherapy group than in the nonchemotherapy group (3.1% vs 10.4%, P = .044). After adjustment for clinically relevant factors such as body mass index, aspirin use, metformin use, number of follow-up colonoscopies, and operation type, adjuvant chemotherapy was found to be associated with a decreased incidence of advanced adenoma (odds ratio, .151; 95% confidence interval, .035-.653; P = .011) in patients with stage II CRC. CONCLUSIONS: The results showed that chemotherapy in patients with CRC may be associated with a lower risk of colorectal advanced adenoma development. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Mosby Yearbook | - |
dc.relation.isPartOf | GASTROINTESTINAL ENDOSCOPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Postoperative adjuvant chemotherapy is associated with a lower incidence of colorectal adenomas in patients with previous colorectal cancer. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Hee Seung Lee | - |
dc.contributor.googleauthor | Sung Bae Kim | - |
dc.contributor.googleauthor | Hyun Jung Lee | - |
dc.contributor.googleauthor | Soo Jung Park | - |
dc.contributor.googleauthor | Sung Pil Hong | - |
dc.contributor.googleauthor | Jae Hee Cheon | - |
dc.contributor.googleauthor | Won Ho Kim | - |
dc.contributor.googleauthor | Tae Il Kim | - |
dc.identifier.doi | 10.1016/j.gie.2017.04.004 | - |
dc.contributor.localId | A00570 | - |
dc.contributor.localId | A00774 | - |
dc.contributor.localId | A01079 | - |
dc.contributor.localId | A01539 | - |
dc.contributor.localId | A03349 | - |
dc.contributor.localId | A04030 | - |
dc.contributor.localId | A04404 | - |
dc.relation.journalcode | J00920 | - |
dc.identifier.eissn | 1097-6779 | - |
dc.identifier.pmid | 28431950 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0016510717318060 | - |
dc.contributor.alternativeName | Kim, Sung Bae | - |
dc.contributor.alternativeName | Kim, Won Ho | - |
dc.contributor.alternativeName | Kim, Tae Il | - |
dc.contributor.alternativeName | Park, Soo Jung | - |
dc.contributor.alternativeName | Lee, Hee Seung | - |
dc.contributor.alternativeName | Cheon, Jae Hee | - |
dc.contributor.alternativeName | Hong, Sung Pil | - |
dc.contributor.affiliatedAuthor | Kim, Sung Bae | - |
dc.contributor.affiliatedAuthor | Kim, Won Ho | - |
dc.contributor.affiliatedAuthor | Kim, Tae Il | - |
dc.contributor.affiliatedAuthor | Park, Soo Jung | - |
dc.contributor.affiliatedAuthor | Lee, Hee Seung | - |
dc.contributor.affiliatedAuthor | Cheon, Jae Hee | - |
dc.contributor.affiliatedAuthor | Hong, Sung Pil | - |
dc.citation.volume | 87 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 688 | - |
dc.citation.endPage | 694 | - |
dc.identifier.bibliographicCitation | GASTROINTESTINAL ENDOSCOPY, Vol.87(3) : 688-694, 2018 | - |
dc.identifier.rimsid | 58560 | - |
dc.type.rims | ART | - |
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