Cited 11 times in
Toward safer prescribing: Evaluation of a prospective Drug Utilization Review system on inappropriate prescriptions, prescribing patterns, and adverse drug events and related health expenditure in South Korea
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박은철 | - |
dc.date.accessioned | 2018-09-28T08:56:59Z | - |
dc.date.available | 2018-09-28T08:56:59Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0033-3506 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/163256 | - |
dc.description.abstract | OBJECTIVES: This study aimed to evaluate the effect of the prospective drug utilization review (DUR) system introduced in Korea in December 2010 as a real-time method to improve patient safety, in terms of changes in prescribing practices, adverse drug events (ADEs), and ADE-related healthcare expenditure, using non-steroidal anti-inflammatory drugs (NSAIDs) and their common ADEs as a guide. STUDY DESIGN: We used an interrupted time-series study design using generalized estimating equations to evaluate changes in prescription rate and ADE-related healthcare expenditure. Cox regression analysis was used to evaluate the probability of NSAID-associated ADEs. METHODS: A total of 154,585 outpatients with musculoskeletal or connective tissue disorders, without pre-existing gastric bleeding or ulcers were included in this study. The primary outcome was the level and trend change in prescription rate, drug-drug interactions, coprescribed gastro-protective drugs, and defined daily dose (DDD) of NSAIDs. The secondary outcome was the probability of ADEs and changes in ADE-related healthcare expenditure. RESULTS: There was a significant trend change after introducing the DUR system in terms of drug-drug interactions (-3.6%) and coprescribed gastro-protective drugs (+0.6%). The mean DDD of NSAIDs increased by 0.2. The probability of ADEs decreased overall (-1.7%) and in the high-risk group (age ≥65 years; -9.6%); however, only the latter was significant. There was no significant trend or level change in ADE-related health expenditure. CONCLUSIONS: The introduction of the DUR system was associated with more efficient prescribing, including a reduction in drug-drug interactions and an increase in the use of gastro-protective drugs. The system had a positive effect on patient outcome but was not associated with reduced ADE-related costs. Further studies are needed to evaluate the long-term effects of the DUR system in Korea. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | PUBLIC HEALTH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Toward safer prescribing: Evaluation of a prospective Drug Utilization Review system on inappropriate prescriptions, prescribing patterns, and adverse drug events and related health expenditure in South Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Preventive Medicine | - |
dc.contributor.googleauthor | S.J. Kim | - |
dc.contributor.googleauthor | K.-T. Han | - |
dc.contributor.googleauthor | H.-G. Kang | - |
dc.contributor.googleauthor | E.-C. Park | - |
dc.identifier.doi | 10.1016/j.puhe.2018.06.009 | - |
dc.contributor.localId | A01618 | - |
dc.relation.journalcode | J02579 | - |
dc.identifier.eissn | 1476-5616 | - |
dc.identifier.pmid | 30145461 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0033350618302142 | - |
dc.subject.keyword | Drug utilization review | - |
dc.subject.keyword | Drug-related side-effects and adverse reactions | - |
dc.subject.keyword | Health expenditure | - |
dc.subject.keyword | Prescription drug misuse | - |
dc.contributor.alternativeName | Park, Eun Chul | - |
dc.contributor.affiliatedAuthor | Park, Eun Chul | - |
dc.citation.volume | 163 | - |
dc.citation.startPage | 128 | - |
dc.citation.endPage | 136 | - |
dc.identifier.bibliographicCitation | PUBLIC HEALTH, Vol.163 : 128-136, 2018 | - |
dc.identifier.rimsid | 58522 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.