Cited 16 times in
A brief review of relationship between occupational benzene exposure and hematopoietic cancer
DC Field | Value | Language |
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dc.contributor.author | 윤진하 | - |
dc.date.accessioned | 2018-09-28T08:56:38Z | - |
dc.date.available | 2018-09-28T08:56:38Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1225-3618 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/163249 | - |
dc.description.abstract | We reviewed articles to clarify the current evidence status for 1) types of cancer which related to benzene exposure, and 2) certain benzene exposure level which might cause the hematopoietic cancers. Hematopoietic function of the bone marrow is involved in the production of all blood cells types. The benzene metabolites including benzoquinone and mucoaldehyde affect hematopoietic stem cells as well as differentiation steps of progenitor cells for each blood cell. Hence, we concluded that benzene was associated with all lymphohematic carcinogenesis. First, it is supported by biological plausibility. Second, it is supported by meta-analysis although sing study did not show relationship due to lack of sample size or statistical power. More recent studies show lesser exposed level related to risk of cancer, compare to past studies did. Actually, early studies show the risk of malignancies in workers who exposed more than 200 ppm-years. However, only 0.5 to 1 ppm-year benzene exposed show significant linking to risk of malignancies in recent study. As reviewed research articles, we concluded that the relatively lower exposure level, such as 0.5-1 ppm-year, will be considering at risk of hematopoietic cancer. However, more research needs to be done on dose-response analysis. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한산업의학회 | - |
dc.relation.isPartOf | Korean Journal of Occupational and Environmental Medicine (대한산업의학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | A brief review of relationship between occupational benzene exposure and hematopoietic cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Preventive Medicine | - |
dc.contributor.googleauthor | Jin-Ha Yoon | - |
dc.contributor.googleauthor | Woo Seok Kwak | - |
dc.contributor.googleauthor | Yeon-Soon Ahn | - |
dc.identifier.doi | 10.1186/s40557-018-0245-9 | - |
dc.contributor.localId | A04616 | - |
dc.relation.journalcode | J02077 | - |
dc.identifier.pmid | 29760933 | - |
dc.subject.keyword | Benzene | - |
dc.subject.keyword | Hematopoietic cancer | - |
dc.subject.keyword | Leukemia | - |
dc.contributor.alternativeName | Yoon, Jin Ha | - |
dc.contributor.affiliatedAuthor | Yoon, Jin Ha | - |
dc.citation.volume | 30 | - |
dc.citation.startPage | 33 | - |
dc.identifier.bibliographicCitation | Korean Journal of Occupational and Environmental Medicine (대한산업의학회지), Vol.30 : 33, 2018 | - |
dc.identifier.rimsid | 58516 | - |
dc.type.rims | ART | - |
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